Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans
文献类型：期刊论文
| 作者 | Li, Qin1; Chen, Chunmei1; He, Yan3; Guan, Danyingzi1; Cheng, Li1,2; Hao, Xincai2; Wei, Mengsha1; Zheng, Yinyu1; Liu, Chang1; Li, Xiao-Nian4 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-07-05 |
| 卷号 | 21期号:13页码:5091-5095 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b01680 |
| 通讯作者 | Zhu, Hucheng(zhuhucheng@hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn) |
| 英文摘要 | Emeriones A-C (1-3), three highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane functionalities, were isolated from Emericella nidulans. An additional peroxide bridge in compound 3 led to the construction of an unexpected 7,8-dioxatricyclo[4.2.2.0(2,5)] decene scaffold. The structures of 1-3 were elucidated by comprehensive spectroscopic techniques, and their absolute configurations were confirmed by single-crystal X-ray crystallographic analyses and ECD calculations. Compound 1 shows weak inhibitory effects on NO production in LPS-induced RAW264.7 cells. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000474795200036 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67960]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhu, Hucheng; Zhang, Yonghui |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Hubei Univ Med, Coll Pharm, Hubei Engn Technol Ctr Comprehens Utilizat Med Pl, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qin,Chen, Chunmei,He, Yan,et al. Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans[J]. ORGANIC LETTERS,2019,21(13):5091-5095. |
| APA | Li, Qin.,Chen, Chunmei.,He, Yan.,Guan, Danyingzi.,Cheng, Li.,...&Zhang, Yonghui.(2019).Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans.ORGANIC LETTERS,21(13),5091-5095. |
| MLA | Li, Qin,et al."Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans".ORGANIC LETTERS 21.13(2019):5091-5095. |
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来源：昆明植物研究所
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