Repeated fluoxetine treatment induces long-lasting neurotrophic changes in the medial prefrontal cortex of adult rats
文献类型：期刊论文
| 作者 | Lei, Hao4,5; Zou, Yijuan4,5; Gao, Lifeng1,4; Rao, Xiaoping2; Xu, Hui4; Li, Ronghui4,5; Wu, Hao3; Song, Tao4,5 |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2019-06-03 |
| 卷号 | 365页码:114-124 |
| 关键词 | Fluoxetine Prefrontal cortex Parvalbumin Neuroplasticity Brain-derived neurotrophic factor Y-maze |
| ISSN号 | 0166-4328 |
| DOI | 10.1016/j.bbr.2019.03.009 |
| 英文摘要 | Fluoxetine (Flx), a selective serotonin reuptake inhibitor, is extensively used to treat mood and anxiety disorders. Previous animal studies have shown that early-life exposure to Flx results in long-lasting behavioral alterations and neuroplasticity in the hippocampus and cortex, which may persist into adulthood. It remains unclear whether repeated Flx treatment in normal adult animals can induce lasting neuroplasticity and behavioral alterations persisting long beyond the treatment period. In this study, young adult rats (about 9 weeks old) were treated with Flx (10 mg/kg body weight, twice daily) for 15 consecutive days, and the effects of Flx on medial prefrontal cortex (mPFC) neuroplasticity and mPFC-related behaviors were assessed 20 days after the last injection. It was observed that the mPFC of Flx-treated rats had significant increases in the number of 5-bromo-deoxyuridine-positive (BrdU(+)) cells, dendritic complexity/spine density in layer II/III pyramidal neurons, and brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) expression levels, as well as a significant decrease in the number of parvalbumin-positive (PV+) interneurons. The Flx-treated rats exhibited higher motivation to explore new environments, evidenced by a significantly increased number of entries into the novel arm in the Y-maze test. However, they did not show any significant changes in the anhedonia and anxiety levels measured by sucrose preference and elevated plus maze tests respectively. In conclusion, repeated Flx treatment, with the paradigm used, induces long-lasting neuroplastic changes in the mPFC of normal adult rats; such changes and related behavioral manifestations may persist up to 20 days after the last dose. |
| WOS关键词 | ANXIETY-LIKE BEHAVIORS ; HIPPOCAMPAL BDNF GENE ; CELL-PROLIFERATION ; TREATMENT INCREASES ; FRONTAL-CORTEX ; SHORT-TERM ; ANTIDEPRESSANT ; STRESS ; EXPRESSION ; PLASTICITY |
| 资助项目 | National Natural Science Foundation of China[21790390] ; National Natural Science Foundation of China[21790392] ; National Natural Science Foundation of China[81601204] ; K. C. Wong Educational Foundation |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000463463200014 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/13729]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Lei, Hao |
| 作者单位 | 1.Jianghan Univ, Sch Med, Dept Med Imaging, Wuhan 430056, Hubei, Peoples R China 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Ctr Brain Sci,Natl Ctr Magnet Resonance Wuhan,Wuh, Wuhan 430071, Hubei, Peoples R China 3.Army Med Univ, Affiliated Hosp 3, Inst Surg Res, Dept Radiol, Chongqing 400042, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China 5.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Hao,Zou, Yijuan,Gao, Lifeng,et al. Repeated fluoxetine treatment induces long-lasting neurotrophic changes in the medial prefrontal cortex of adult rats[J]. BEHAVIOURAL BRAIN RESEARCH,2019,365:114-124. |
| APA | Lei, Hao.,Zou, Yijuan.,Gao, Lifeng.,Rao, Xiaoping.,Xu, Hui.,...&Song, Tao.(2019).Repeated fluoxetine treatment induces long-lasting neurotrophic changes in the medial prefrontal cortex of adult rats.BEHAVIOURAL BRAIN RESEARCH,365,114-124. |
| MLA | Lei, Hao,et al."Repeated fluoxetine treatment induces long-lasting neurotrophic changes in the medial prefrontal cortex of adult rats".BEHAVIOURAL BRAIN RESEARCH 365(2019):114-124. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。