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Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR

文献类型：期刊论文

作者Zhou, Xin2,3; Ye, Chaohui2,3; Wu, Guangyao1; Sun, Xianping2,3; Yang, Hao1; Wang, Ke1; Deng, He2,3; Xiao, Sa2,3; Zhang, Ming3; Shi, Lei2,3
刊名NMR IN BIOMEDICINE
出版日期2019-05-01
卷号32期号:5页码:11
ISSN号0952-3480
关键词compressed sensing COPD gas exchange hyperpolarized Xe-129 lung pulmonary microstructure
DOI10.1002/nbm.4068
英文摘要Pulmonary diseases usually result in changes of the blood-gas exchange function in the early stages. Gas exchange across the respiratory membrane and gas diffusion in the alveoli can be quantified using hyperpolarized Xe-129 MR via chemical shift saturation recovery (CSSR) and diffusion-weighted imaging (DWI), respectively. Generally, CSSR and DWI data have been collected in separate breaths in humans. Unfortunately, the lung inflation level cannot be the exactly same in different breaths, which causes fluctuations in blood-gas exchange and pulmonary microstructure. Here we combine CSSR and DWI obtained with compressed sensing, to evaluate the gas diffusion and exchange function within a single breath-hold in humans. A new parameter, namely the perfusion factor of the respiratory membrane (SVRd/g), is proposed to evaluate the gas exchange function. Hyperpolarized Xe-129 MR data are compared with pulmonary function tests and computed tomography examinations in healthy young, age-matched control, and chronic obstructive pulmonary disease human cohorts. SVRd/g decreases as the ventilation impairment and emphysema index increase. Our results indicate that the proposed method has the potential to detect the extent of lung parenchyma destruction caused by age and pulmonary diseases, and it would be useful in the early diagnosis of pulmonary diseases in clinical practice.
WOS关键词MAGNETIC-RESONANCE ; LUNG-FUNCTION ; XENON NMR ; ACQUISITION ; POLARIZATION ; PERFUSION ; HEALTHY ; DISEASE ; MODEL
资助项目Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SLH018] ; National Key R&D Program of China[2016YFC1304700] ; National Key R&D Program of China[2017YFA0505400] ; National Natural Science Foundation of China[81227902] ; National Natural Science Foundation of China[81601491] ; National Natural Science Foundation of China[81625011] ; Hubei Provincial Natural Science Foundation of China[2017CFA013] ; Hubei Provincial Natural Science Foundation of China[2018ACA143] ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals)
WOS研究方向Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
语种英语
出版者WILEY
WOS记录号WOS:000465199500010
资助机构Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals)
源URL[http://ir.wipm.ac.cn/handle/112942/13815]  
专题中国科学院武汉物理与数学研究所
通讯作者Zhou, Xin
作者单位1.Wuhan Univ, Zhongnan Hosp, Dept Radiol, Wuhan, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Xin,Ye, Chaohui,Wu, Guangyao,et al. Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR[J]. NMR IN BIOMEDICINE,2019,32(5):11.
APA Zhou, Xin.,Ye, Chaohui.,Wu, Guangyao.,Sun, Xianping.,Yang, Hao.,...&Xie, Junshuai.(2019).Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR.NMR IN BIOMEDICINE,32(5),11.
MLA Zhou, Xin,et al."Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR".NMR IN BIOMEDICINE 32.5(2019):11.

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来源：武汉物理与数学研究所

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