Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
文献类型：期刊论文
| 作者 | Liu, Caixiang2; Hu, Limin3; Yang, Wenzhi3; Dou, Zhiying3; Zheng, Fang3; Zhao, Qianyu3; Wang, Yulan1,2; Wang, Piao3; Han, Lifeng2,3 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2019-04-16 |
| 卷号 | 10页码:12 |
| 关键词 | Polygonum multiflorum metabolomics hepatotoxicity L02 cell UHPLC/Q-Orbitrap-MS |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2019.00329 |
| 英文摘要 | The dry roots of Polygonum multiflorum (PM), involving both the raw and processed materials, are widely used as the traditional Chinese medicine for treating various diseases in China. Hepatotoxicity has been occasionally reported in patients who consume PM. Unfortunately, no definite criteria are currently available regarding the processing technology of PM for reduction the toxicity. In this work, we aimed to investigate the variations of PM metabolite profiles induced by different processing technologies by UHPLC/Q-Orbitrap-MS and multivariate statistical analysis, and to discover the potential toxic compounds by correlating the cytotoxicity of L02 cell with the contents of metabolites in raw and processed PM samples. We could identify two potential toxic compounds, emodin-8-O-glucoside and torachrysone-O-hexose, which could be selected as the toxic markers to evaluate different processing methods. The results indicated all processed PM samples could decrease the cytotoxicity on L02 cell. The best processing technology for PM process was to steam PM in black soybean decoction (BD-PM) for 24 h. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; TIME-OF-FLIGHT ; ANTIOXIDANT PHENOLIC-COMPOUNDS ; IDIOSYNCRATIC HEPATOTOXICITY ; STILBENE GLUCOSIDE ; ACUTE HEPATITIS ; CONSTITUENTS ; COMPONENTS ; ANTHRAQUINONES ; IDENTIFICATION |
| 资助项目 | Important Drug Development Fund, Ministry of Science and Technology of China[2015ZX09501004-003-004] ; Program for National Natural Science Foundation of China[81703934] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000465027700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Important Drug Development Fund, Ministry of Science and Technology of China ; Important Drug Development Fund, Ministry of Science and Technology of China ; Program for National Natural Science Foundation of China ; Program for National Natural Science Foundation of China ; Important Drug Development Fund, Ministry of Science and Technology of China ; Important Drug Development Fund, Ministry of Science and Technology of China ; Program for National Natural Science Foundation of China ; Program for National Natural Science Foundation of China ; Important Drug Development Fund, Ministry of Science and Technology of China ; Important Drug Development Fund, Ministry of Science and Technology of China ; Program for National Natural Science Foundation of China ; Program for National Natural Science Foundation of China ; Important Drug Development Fund, Ministry of Science and Technology of China ; Important Drug Development Fund, Ministry of Science and Technology of China ; Program for National Natural Science Foundation of China ; Program for National Natural Science Foundation of China |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/13826]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Liu, Caixiang; Wang, Yulan |
| 作者单位 | 1.Nanyang Technol Univ, Sch Biol Sci, Lee Kong Chian Sch Med, Singapore Phenome Ctr, Nanyang, Singapore 2.Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan, Hubei, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin State Key Lab Modern Chinese Med, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Caixiang,Hu, Limin,Yang, Wenzhi,et al. Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis[J]. FRONTIERS IN PHARMACOLOGY,2019,10:12. |
| APA | Liu, Caixiang.,Hu, Limin.,Yang, Wenzhi.,Dou, Zhiying.,Zheng, Fang.,...&Han, Lifeng.(2019).Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis.FRONTIERS IN PHARMACOLOGY,10,12. |
| MLA | Liu, Caixiang,et al."Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis".FRONTIERS IN PHARMACOLOGY 10(2019):12. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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