Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory
文献类型:期刊论文
作者 | He, Jufang8,9; Xu, Fuqiang7; Guo, Yiping6; Tortorella, Micky6; Chan, Ying-Shing2,3; Yung, Ken K. L.1; Shum, Daisy Kwok-Yan2,3; Cheung, Hon-Yeung9; Wang, Xiaoyu8,9; Wong, Kelvin9 |
刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
出版日期 | 2019-03-26 |
卷号 | 116期号:13页码:6397-6406 |
ISSN号 | 0027-8424 |
关键词 | cholecystokinin NMDA receptor long-term potentiation memory entorhinal cortex |
DOI | 10.1073/pnas.1816833116 |
英文摘要 | Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK-/- mice lacked neocortical LTP and showed deficits in a cue-cue associative learning paradigm; and administration of CCK rescued associative learning deficits. High-frequency stimulation-induced neocortical LTP was completely blocked by either the NMDAR antagonist or the CCKBR antagonist, while application of either NMDA or CCK induced LTP after low-frequency stimulation. In the presence of CCK, LTP was still induced even after blockade of NMDARs. Local application of NMDA induced the release of CCK in the neocortex. These findings suggest that NMDARs control the release of CCK, which enables neocortical LTP and the formation of cue-cue associative memory. |
WOS关键词 | LONG-TERM POTENTIATION ; MICE LACKING ; AMPA RECEPTORS ; RAT ; NEURONS ; CORTEX ; TRANSMISSION ; STIMULATION ; INHIBITION ; ANTAGONIST |
资助项目 | Hong Kong Research Grants Council ; Guangdong Science and Technology Foundation ; Natural Science Foundation of China ; Health and Medical Research Fund ; Innovation and Technology Fund[C1014-15G] ; Innovation and Technology Fund[MRP/101/17X] ; Innovation and Technology Fund[31571096] ; Innovation and Technology Fund[31371114] ; Innovation and Technology Fund[31671102] ; Innovation and Technology Fund[31200852] ; Innovation and Technology Fund[31171060] ; Innovation and Technology Fund[03141196] ; Innovation and Technology Fund[01121906] ; Innovation and Technology Fund[561313M] ; Innovation and Technology Fund[11101215M] ; Innovation and Technology Fund[11166316M] ; Innovation and Technology Fund[11102417M] ; Innovation and Technology Fund[11101818M] ; Innovation and Technology Fund[2014B050505016] ; Charlie Lee Charitable Foundation ; Fong Shu Fook Tong Foundation ; Croucher Foundation |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATL ACAD SCIENCES |
WOS记录号 | WOS:000462382800086 |
资助机构 | Hong Kong Research Grants Council ; Hong Kong Research Grants Council ; Guangdong Science and Technology Foundation ; Guangdong Science and Technology Foundation ; Natural Science Foundation of China ; Natural Science Foundation of China ; Health and Medical Research Fund ; Health and Medical Research Fund ; Innovation and Technology Fund ; Innovation and Technology Fund ; Charlie Lee Charitable Foundation ; Charlie Lee Charitable Foundation ; Fong Shu Fook Tong Foundation ; Fong Shu Fook Tong Foundation ; Croucher Foundation ; Croucher Foundation ; Hong Kong Research Grants Council ; Hong Kong Research Grants Council ; Guangdong Science and Technology Foundation ; Guangdong Science and Technology Foundation ; Natural Science Foundation of China ; Natural Science Foundation of China ; Health and Medical Research Fund ; Health and Medical Research Fund ; Innovation and Technology Fund ; Innovation and Technology Fund ; Charlie Lee Charitable Foundation ; Charlie Lee Charitable Foundation ; Fong Shu Fook Tong Foundation ; Fong Shu Fook Tong Foundation ; Croucher Foundation ; Croucher Foundation ; Hong Kong Research Grants Council ; Hong Kong Research Grants Council ; Guangdong Science and Technology Foundation ; Guangdong Science and Technology Foundation ; Natural Science Foundation of China ; Natural Science Foundation of China ; Health and Medical Research Fund ; Health and Medical Research Fund ; Innovation and Technology Fund ; Innovation and Technology Fund ; Charlie Lee Charitable Foundation ; Charlie Lee Charitable Foundation ; Fong Shu Fook Tong Foundation ; Fong Shu Fook Tong Foundation ; Croucher Foundation ; Croucher Foundation ; Hong Kong Research Grants Council ; Hong Kong Research Grants Council ; Guangdong Science and Technology Foundation ; Guangdong Science and Technology Foundation ; Natural Science Foundation of China ; Natural Science Foundation of China ; Health and Medical Research Fund ; Health and Medical Research Fund ; Innovation and Technology Fund ; Innovation and Technology Fund ; Charlie Lee Charitable Foundation ; Charlie Lee Charitable Foundation ; Fong Shu Fook Tong Foundation ; Fong Shu Fook Tong Foundation ; Croucher Foundation ; Croucher Foundation |
源URL | [http://ir.wipm.ac.cn/handle/112942/13981] |
专题 | 中国科学院武汉物理与数学研究所 |
通讯作者 | He, Jufang |
作者单位 | 1.Hong Kong Baptist Univ, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China 2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China 3.Univ Hong Kong, Li Ka Shing Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China 4.Hangzhou Normal Univ, Sch Med, Hangzhou 310018, Zhejiang, Peoples R China 5.Harbin Inst Technol, Sch Life Sci, Harbin 150006, Heilongjiang, Peoples R China 6.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China 7.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Ctr Brain Sci,State Key Lab Magnet Resonance & At, Wuhan 430071, Hubei, Peoples R China 8.City Univ Hong Kong Shenzhen Res Inst, Shenzhen 518057, Peoples R China 9.City Univ Hong Kong, Dept Biomed Sci, Kowloon Tong, Hong Kong, Peoples R China |
推荐引用方式 GB/T 7714 | He, Jufang,Xu, Fuqiang,Guo, Yiping,et al. Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(13):6397-6406. |
APA | He, Jufang.,Xu, Fuqiang.,Guo, Yiping.,Tortorella, Micky.,Chan, Ying-Shing.,...&Chen, Xi.(2019).Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(13),6397-6406. |
MLA | He, Jufang,et al."Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.13(2019):6397-6406. |
入库方式: OAI收割
来源:武汉物理与数学研究所
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