Solution NMR structure of CHU_1110 from Cytophaga hutchinsonii, an AHSA1 protein potentially involved in metal ion stress response
文献类型：期刊论文
| 作者 | Yang, Yunhuang5; He, Ting5; Liu, Maili5; Li, Xuegang1; Yue, Xiali1; Kennedy, Michael A.2,3; Ramelot, Theresa A.2,3; Zhu, Jiang5; Liang, Chunjie4,5 |
| 刊名 | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
 |
| 出版日期 | 2019 |
| 卷号 | 87期号:1页码:91-95 |
| ISSN号 | 0887-3585 |
| 关键词 | ATPase homolog 1 family CHU_1110 metal ion stress NMR solution structure |
| DOI | 10.1002/prot.25622 |
| 英文摘要 | We report the solution nuclear magnetic resonance (NMR) structure of CHU_1110 from Cytophaga hutchinsonii. CHU_1110 contains three alpha-helices and one antiparallel beta-sheet, forming a large cavity in the center of the protein, which are consistent with the structural characteristics of AHSA1 protein family. This protein shows high structural similarities to the prokaryotic proteins RHE_CH02687 from Rhizobium etli and YndB from Bacillus subtilis, which can bind with flavinoids. Unlike these two homologs, CHU_1110 shows no obvious interaction with flavonoids in NMR titration experiments. In addition, no direct interaction has been observed between CHU_1110 and ATP, although many homologous sequences of CHU_1110 have been annotated as ATPase. Combining the analysis of structural similarity of CHU_1110 and genomic context of its encoding gene, we speculate that CHU_1110 may be involved in the stress response of bacteria to heavy metal ions, even though its specific biological functions that need to be further investigated. |
| WOS关键词 | FUNCTIONAL ASSOCIATIONS |
| 资助项目 | National Natural Sciences Foundation of China[21575155] ; National Institute of General Medical Sciences of USA[U54-GM094597] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000454534600010 |
| 资助机构 | National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; National Institute of General Medical Sciences of USA ; National Institute of General Medical Sciences of USA ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; National Institute of General Medical Sciences of USA ; National Institute of General Medical Sciences of USA ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; National Institute of General Medical Sciences of USA ; National Institute of General Medical Sciences of USA ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; National Institute of General Medical Sciences of USA ; National Institute of General Medical Sciences of USA |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/13979]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Yang, Yunhuang; He, Ting |
| 作者单位 | 1.Huazhong Agr Univ, Dept Chem, Coll Sci, Wuhan, Hubei, Peoples R China 2.Miami Univ, Northeast Struct Genom Consortium, Oxford, OH 45056 USA 3.Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom Mol Phys, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yunhuang,He, Ting,Liu, Maili,et al. Solution NMR structure of CHU_1110 from Cytophaga hutchinsonii, an AHSA1 protein potentially involved in metal ion stress response[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2019,87(1):91-95. |
| APA | Yang, Yunhuang.,He, Ting.,Liu, Maili.,Li, Xuegang.,Yue, Xiali.,...&Liang, Chunjie.(2019).Solution NMR structure of CHU_1110 from Cytophaga hutchinsonii, an AHSA1 protein potentially involved in metal ion stress response.PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,87(1),91-95. |
| MLA | Yang, Yunhuang,et al."Solution NMR structure of CHU_1110 from Cytophaga hutchinsonii, an AHSA1 protein potentially involved in metal ion stress response".PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 87.1(2019):91-95. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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