Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production
文献类型：期刊论文
| 作者 | Ye, Jing2,3,4; Cao, Shengbo2,3,4; Chen, Huanchun2,3,4; Song, Yunfeng2,3,4; Cui, Min2,3,4; Zhao, Zikai2,3,4; Chen, Zheng2,3,4; Zhang, Luping2,3,4; Li, Qiuyan2,3,4; Jia, Fan1 |
| 刊名 | VIROLOGICA SINICA
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 33期号:6页码:515-523 |
| 关键词 | Japanese encephalitis virus (JEV) NS1 Type I interferon (IFN-I) Immune evasion |
| ISSN号 | 1674-0769 |
| DOI | 10.1007/s12250-018-0067-5 |
| 英文摘要 | Japanese encephalitis virus (JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1, a 52-amino acid C-terminal extension of NS1, is generated with a -1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1 plays a vital role in virulence, but the mechanism is unclear. In this study, an NS1 defected (rG66A) virus was generated. We found that rG66A virus was less virulent than its parent virus (pSA14) in wild-type mice. However, similar mortality caused by the two viruses was observed in an IFNAR knockout mouse model. Moreover, we found that rG66A virus induced a greater type I interferon (IFN) response than that by pSA14, and JEV NS1 significantly inhibited the production of IFN- and IFN-stimulated genes. Taken together, our results reveal that NS1 plays a vital role in blocking type I IFN production to help JEV evade antiviral immunity and benefit viral replication. |
| WOS关键词 | WEST-NILE ; FLAVIVIRUSES ; PATHOGENESIS ; CONTRIBUTES ; MUTATION ; NS2A |
| 资助项目 | National Key Research and Development Program of China[2016YFD0500407] ; National Natural Science Foundation of China[31502065] ; National Natural Science Foundation of China[31572517] ; Fundamental Research Funds for the Central Universities[2013PY051] ; Fundamental Research Funds for the Central Universities[2662016Q003] ; Fundamental Research Funds for the Central Universities[2662015PY083] |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000455958600007 |
| 出版者 | SPRINGER |
| 资助机构 | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/14126]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Ye, Jing |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430070, Hubei, Peoples R China 2.Huazhong Agr Univ, Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Hubei, Peoples R China 3.Huazhong Agr Univ, Coll Vet Med, Key Lab Prevent Vet Med Hubei Prov, Wuhan 430070, Hubei, Peoples R China 4.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Jing,Cao, Shengbo,Chen, Huanchun,et al. Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production[J]. VIROLOGICA SINICA,2018,33(6):515-523. |
| APA | Ye, Jing.,Cao, Shengbo.,Chen, Huanchun.,Song, Yunfeng.,Cui, Min.,...&Zhou, Dengyuan.(2018).Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production.VIROLOGICA SINICA,33(6),515-523. |
| MLA | Ye, Jing,et al."Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production".VIROLOGICA SINICA 33.6(2018):515-523. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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