Peptidic Monodisperse PEG "combs" with Fine-Tunable LCST and Multiple Imaging Modalities
文献类型：期刊论文
| 作者 | Jiang, Zhong-Xing3; Zhou, Xin1; Zheng, Xing2; Chen, Shizhen1; Yang, Zhigang3; Yuan, Yaping1; Li, Yu3; Zhang, Huaibin3; Xiao, Yan2; Zhu, Junfei3 |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 20期号:3页码:1281-1287 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/acs.biomac.8b01693 |
| 英文摘要 | Thermosensitive and imaging-traceable materials with fine-tunable lower critical solution temperature (LCST) around body temperature are highly valuable in biomedicine. However, such materials are rare because it is challenging to fine-tune the LCST and incorporate suitable imaging modalities. Herein, peptidic monodisperse polyethylene glycol (M-PEG) "combs" with fine-tunable LCST, "hot spot" fluorine-19 magnetic resonance imaging (F-19 MRI), thermoresponsive fluorescent imaging, and drug loading ability were developed through accurately programming their structures during solid phase peptide synthesis (SPPS). The easy availability, structural accuracy, biocompatibility, and versatility provide the M-PEG "combs" with promising prospects as thermoresponsive and imaging-traceable biomaterials for controlled drug delivery. |
| WOS关键词 | DRUG-DELIVERY ; THERMOSENSITIVE LIPOSOMES ; POLYMERIC MICELLES ; MOLECULAR-WEIGHT ; COPOLYMERS ; BLOCK ; NANOPARTICLES ; NANOCARRIERS ; HYDROGELS ; RELEASE |
| 资助项目 | National Key R&D Program of China[2016YFC1304704] ; National Natural Science Foundation of China[21572168] ; National Natural Science Foundation of China[81625011] ; Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SLH018] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000461270500015 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/14244]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Jiang, Zhong-Xing |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan 430071, Peoples R China 2.Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China 3.Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhong-Xing,Zhou, Xin,Zheng, Xing,et al. Peptidic Monodisperse PEG "combs" with Fine-Tunable LCST and Multiple Imaging Modalities[J]. BIOMACROMOLECULES,2019,20(3):1281-1287. |
| APA | Jiang, Zhong-Xing.,Zhou, Xin.,Zheng, Xing.,Chen, Shizhen.,Yang, Zhigang.,...&Zhu, Junfei.(2019).Peptidic Monodisperse PEG "combs" with Fine-Tunable LCST and Multiple Imaging Modalities.BIOMACROMOLECULES,20(3),1281-1287. |
| MLA | Jiang, Zhong-Xing,et al."Peptidic Monodisperse PEG "combs" with Fine-Tunable LCST and Multiple Imaging Modalities".BIOMACROMOLECULES 20.3(2019):1281-1287. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。