Enzyme-responsive multistage vector for drug delivery to tumor tissue
文献类型：期刊论文
| 作者 | Mi, Yu4; Wolfram, Joy3,4; Mu, Chaofeng4; Liu, Xuewu4; Blanco, Elvin4; Shen, Haifa2,4; Ferrari, Mauro1,4 |
| 刊名 | PHARMACOLOGICAL RESEARCH
 |
| 出版日期 | 2016-11-01 |
| 卷号 | 113页码:92-99 |
| ISSN号 | 1043-6618 |
| 关键词 | Enzyme-responsive release Lung metastasis MMP2 Multistage vector Porous silicon |
| DOI | 10.1016/j.phrs.2016.08.024 |
| 通讯作者 | Ferrari, Mauro(mferrari@houstonmethodist.org) |
| 英文摘要 | Various nanodelivery systems have been designed to release therapeutic agents upon contact with specific enzymes. However, enzyme-triggered release typically takes place in the tissue interstitium, thereby resulting in the extracellular delivery of drugs. Here, we have designed an enzyme-stimulated multistage vector (ESMSV), which enables stimulus-triggered release of drug-encapsulated nanoparticles from a microparticle. Specifically, polymeric nanoparticles with a surface matrix metalloproteinase-2 (MMP2) peptide substrate were conjugated to the surface of porous silicon microparticles. In the presence of MMP2, the polymeric nanoparticles were released into the tumor interstitium. This platform can be used to attain triggered drug release, while simultaneously facilitating the cellular internalization of drugs. The results indicate that nanoparticle release was MMP2-specific and resulted in improved intracellular uptake of hydrophobic agents in the presence of MMP2. Furthermore, in a mouse model of melanoma lung metastasis, systemic delivery of ESMSVs caused a substantial increase in intracellular accumulation of agents in cancer cells in comparison to delivery with non-stimulus-responsive particles. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | POLYMERIC NANOPARTICLES ; CELLULAR UPTAKE ; MATRIX METALLOPROTEINASES ; BIOLOGICAL BARRIERS ; SIRNA DELIVERY ; GENE DELIVERY ; BREAST-CANCER ; PARTICLE-SIZE ; THERAPEUTICS ; NANOMEDICINE |
| 资助项目 | Houston Methodist Research Institute ; Ernest Cockrell Jr. Distinguished Endowed Chair ; US Department of Defense[W81XWH-09-1-0212] ; National Institute of Health[U54CA143837] ; National Institute of Health[U54CA151668] ; Department of Defense[W81XWH-12-1-0414] ; State of Texas CPRIT[RP121071] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000389086800009 |
| 资助机构 | Houston Methodist Research Institute ; Ernest Cockrell Jr. Distinguished Endowed Chair ; US Department of Defense ; National Institute of Health ; Department of Defense ; State of Texas CPRIT |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/281942]  |
| 专题 | 中国科学院高能物理研究所 |
| 通讯作者 | Ferrari, Mauro |
| 作者单位 | 1.Weill Cornell Med, Dept Med, 1300 York Ave, New York, NY 10065 USA 2.Weill Cornell Med, Dept Cell & Dev Biol, 1300 York Ave, New York, NY 10065 USA 3.Univ Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Houston Methodist Res Inst, Dept Nanomed, 6670 Benner Ave, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Mi, Yu,Wolfram, Joy,Mu, Chaofeng,et al. Enzyme-responsive multistage vector for drug delivery to tumor tissue[J]. PHARMACOLOGICAL RESEARCH,2016,113:92-99. |
| APA | Mi, Yu.,Wolfram, Joy.,Mu, Chaofeng.,Liu, Xuewu.,Blanco, Elvin.,...&Ferrari, Mauro.(2016).Enzyme-responsive multistage vector for drug delivery to tumor tissue.PHARMACOLOGICAL RESEARCH,113,92-99. |
| MLA | Mi, Yu,et al."Enzyme-responsive multistage vector for drug delivery to tumor tissue".PHARMACOLOGICAL RESEARCH 113(2016):92-99. |
入库方式： OAI收割
来源：高能物理研究所
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