中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies

文献类型:期刊论文

作者Zhao LN(赵丽娜); Gao, XY; Zhao, YW; Zhang, P; Yuan, Q; He, J; Zhao, LN; Gao, L; Liu, MQ; Gao XY(高学云)
刊名SCIENTIFIC REPORTS
出版日期2017
卷号7页码:131
ISSN号2045-2322
DOI10.1038/s41598-017-00278-6
文献子类Article
英文摘要The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellular redox level, thus becomes a potential target in cancer treatment. We firstly utilize molecular dynamic ( MD) simulation to rationally design and screen serial peptide-Au cluster compounds with special peptide sequences and precise gold atoms, which can recognize and bind specific domain of GPx-1 with high affinity. The theoretical simulations were further verified by the following peptide-Au clusters synthesis and GPx-1 activity suppression studies in buffer and cells, respectively. Further cytological experiments corroborated that peptide-Au clusters are promising nanoparticles inducing tumor cells apoptosis by suppressing GPx-1 activity and increasing higher cellular reactive oxygen species level to initiate tumor cell apoptosis through intrinsic mitochondrial pathway.
WOS关键词PROTEIN-NANOPARTICLE INTERACTIONS ; MEDIATED MITOCHONDRIAL PATHWAY ; METAL NANOCLUSTERS ; OPTICAL-PROPERTIES ; CHEMICAL-SYNTHESIS ; GOLD NANOCLUSTERS ; ATOMIC PRECISION ; QUANTUM DOTS ; CANCER-CELLS ; INHIBITION
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000396868900013
源URL[http://ir.ihep.ac.cn/handle/311005/284860]  
专题高能物理研究所_多学科研究中心
高能物理研究所_加速器中心
高能物理研究所_粒子天体物理中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714
Zhao LN,Gao, XY,Zhao, YW,et al. Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies[J]. SCIENTIFIC REPORTS,2017,7:131.
APA 赵丽娜.,Gao, XY.,Zhao, YW.,Zhang, P.,Yuan, Q.,...&刘梅青.(2017).Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies.SCIENTIFIC REPORTS,7,131.
MLA 赵丽娜,et al."Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies".SCIENTIFIC REPORTS 7(2017):131.

入库方式: OAI收割

来源:高能物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。