Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies
文献类型：期刊论文
| 作者 | Zhao LN(赵丽娜) ; Gao, XY; Zhao, YW; Zhang, P; Yuan, Q; He, J; Zhao, LN; Gao, L; Liu, MQ; Gao XY(高学云)
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7页码:131 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-00278-6 |
| 文献子类 | Article |
| 英文摘要 | The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellular redox level, thus becomes a potential target in cancer treatment. We firstly utilize molecular dynamic ( MD) simulation to rationally design and screen serial peptide-Au cluster compounds with special peptide sequences and precise gold atoms, which can recognize and bind specific domain of GPx-1 with high affinity. The theoretical simulations were further verified by the following peptide-Au clusters synthesis and GPx-1 activity suppression studies in buffer and cells, respectively. Further cytological experiments corroborated that peptide-Au clusters are promising nanoparticles inducing tumor cells apoptosis by suppressing GPx-1 activity and increasing higher cellular reactive oxygen species level to initiate tumor cell apoptosis through intrinsic mitochondrial pathway. |
| WOS关键词 | PROTEIN-NANOPARTICLE INTERACTIONS ; MEDIATED MITOCHONDRIAL PATHWAY ; METAL NANOCLUSTERS ; OPTICAL-PROPERTIES ; CHEMICAL-SYNTHESIS ; GOLD NANOCLUSTERS ; ATOMIC PRECISION ; QUANTUM DOTS ; CANCER-CELLS ; INHIBITION |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000396868900013 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/284860]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_加速器中心 高能物理研究所_粒子天体物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhao LN,Gao, XY,Zhao, YW,et al. Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies[J]. SCIENTIFIC REPORTS,2017,7:131. |
| APA | 赵丽娜.,Gao, XY.,Zhao, YW.,Zhang, P.,Yuan, Q.,...&刘梅青.(2017).Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies.SCIENTIFIC REPORTS,7,131. |
| MLA | 赵丽娜,et al."Peptide-Au Clusters Induced Tumor Cells Apoptosis via Targeting Glutathione Peroxidase-1: The Molecular Dynamics Assisted Experimental Studies".SCIENTIFIC REPORTS 7(2017):131. |
入库方式： OAI收割
来源：高能物理研究所
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