中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Structural analysis of Wss1 protein from saccharomyces cerevisiae

文献类型:期刊论文

作者Wang, WJ; Dong, YH; Xu, JH; Li, ZQ; Gao, ZQ; Li, YH; Dong YH(董宇辉); Xu JH(徐建华); Gao ZQ(高增强); Li YH(李艳华)
刊名SCIENTIFIC REPORTS
出版日期2017
卷号7页码:8270
ISSN号2045-2322
DOI10.1038/s41598-017-08834-w
文献子类Article
英文摘要Wss1 is a DNA-protein crosslinks (DPCs) repair protein, which is responsible for degradation of the protein components in DPCs. In this investigation, crystal structure of the protease domain from saccharomyces cerevisiae Wss1 (ScWss1) was solved and was compared with the known crystal structure of Schizosaccharomyces prombe Wss1 (SpWss1). It is found that the cleft near zinc ion to be the most conserved core region of Wss1 and that the electronic surface distributions vary greatly between the two homologs. Solution architecture of the full-length ScWss1 was further investigated by small-angle X-ray scattering (SAXS), which indicated the protein contains a flexible region inside. Finally, based on the structural information, a mechanism was proposed about how the enzyme is activated by DNA substrates.
WOS关键词CROSS-LINK REPAIR ; DNA-REPAIR ; SCATTERING ; SYSTEM
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000407570000147
源URL[http://ir.ihep.ac.cn/handle/311005/284863]  
专题高能物理研究所_多学科研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Wang, WJ,Dong, YH,Xu, JH,et al. Structural analysis of Wss1 protein from saccharomyces cerevisiae[J]. SCIENTIFIC REPORTS,2017,7:8270.
APA Wang, WJ.,Dong, YH.,Xu, JH.,Li, ZQ.,Gao, ZQ.,...&Yang, XY.(2017).Structural analysis of Wss1 protein from saccharomyces cerevisiae.SCIENTIFIC REPORTS,7,8270.
MLA Wang, WJ,et al."Structural analysis of Wss1 protein from saccharomyces cerevisiae".SCIENTIFIC REPORTS 7(2017):8270.

入库方式: OAI收割

来源:高能物理研究所

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