ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling
文献类型：期刊论文
| 作者 | Feng, WY ; Li JQ(李金泉); Chen HQ(陈汉清); Wang B(汪冰); Cai CX(蔡承旭); Chai ZF(柴之芳); Feng WY(丰伟悦); Li, JQ; Chen, HQ; Wang, B
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7页码:43126 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep43126 |
| 文献子类 | Article |
| 英文摘要 | Inflammatory bowel diseases (IBD) are widespread inflammatory diseases that cause debilitating health problems including cancer. In this study, we show that ZnO nanoparticle (ZnONP) treatment has markedly dose-dependent effects on the remission of dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We demonstrate the mechanism involves the antioxidant and anti-inflammatory abilities of ZnONPs to suppress ROS and malondialdehyde (MDA) production; increase GSH level; suppress proinflammatory cytokines IL-1 beta and TNF-beta and myeloperoxidase (MPO). The ZnONP treatment is able to activate the Nrf2 pathway in the cellular antioxidant defense system. The novel finding is that ZnONP combined with mesalazine (5-ASA) can enhance the therapeutic efficacy of 5-ASA in the treatment of DSS-induced colitis. Lastly, we found that ZnONP treatment can restore the changes in special colonic bacteria of DSS-mice while the drug 5-ASA cannot. These results indicate that ZnONPs can act as a medical additive for the therapy of IBD. |
| WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; SODIUM-INDUCED COLITIS ; NF-KAPPA-B ; INCREASED SUSCEPTIBILITY ; NRF2-DEFICIENT MICE ; OXIDATIVE STRESS ; MOUSE MODELS ; ZINC ; SULFATE ; PATHOGENESIS |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000394647100001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/284870]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Feng, WY,Li JQ,Chen HQ,et al. ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling[J]. SCIENTIFIC REPORTS,2017,7:43126. |
| APA | Feng, WY.,李金泉.,陈汉清.,汪冰.,蔡承旭.,...&Chai, ZF.(2017).ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling.SCIENTIFIC REPORTS,7,43126. |
| MLA | Feng, WY,et al."ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling".SCIENTIFIC REPORTS 7(2017):43126. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。