The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery
文献类型：期刊论文
| 作者 | Chen, J ; Zhou MX(周梦雪); Wen KK(温凯凯); Chai, ZF; Bai Y(白颖); Lu HR(卢会茹); Chen J(陈俊); Hu Y(胡毅); Chai ZF(柴之芳); Zhou, MX
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| 刊名 | CURRENT TOPICS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2017 |
| 卷号 | 17期号:20页码:2319-2334 |
| 关键词 | Stimuli-response Nanoparticles Drug delivery Tumor microenvironment Chemotherapy |
| ISSN号 | 1568-0266 |
| DOI | 10.2174/1568026617666170224121008 |
| 文献子类 | Review |
| 英文摘要 | Nanocarriers are widely used for delivering drugs to tumors and are progressing in a stable trend, because malignant tumors remain a major health burden throughout the world and effective therapeutic strategies are urgently needed. Furthermore, as an integrated platform, nanocarriers have the potential to dramatically improve cancer diagnosis, imaging, and therapy, while reducing the toxicity associated with the current approaches. Significantly, intelligent nanocarriers are the new generation of the nanocarriers, exhibiting superior tumor targeting and improved therapeutic efficacy. In this review, we discuss recent development in the design of nanoscale stimuli-responsive systems which will be able to control drug biodistribution in response to specific stimuli, either exogenous or endogenous. Meanwhile, the recent progress in engineering intelligent and versatile nanomaterials for targeting the tumor microenvironment is summarized. |
| 电子版国际标准刊号 | 1873-5294 |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; NEAR-INFRARED LIGHT ; BLOCK-COPOLYMER MICELLES ; ENHANCED INTRACELLULAR DELIVERY ; GENERATING LIPOSOMAL SYSTEM ; CELL-PENETRATING PEPTIDES ; IRON-OXIDE NANOPARTICLES ; TUMOR XENOGRAFT MODEL ; GENE DELIVERY ; CANCER-THERAPY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000405625600007 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/284952]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen, J,Zhou MX,Wen KK,et al. The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2017,17(20):2319-2334. |
| APA | Chen, J.,周梦雪.,温凯凯.,Chai, ZF.,白颖.,...&Hu, Y.(2017).The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery.CURRENT TOPICS IN MEDICINAL CHEMISTRY,17(20),2319-2334. |
| MLA | Chen, J,et al."The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery".CURRENT TOPICS IN MEDICINAL CHEMISTRY 17.20(2017):2319-2334. |
入库方式： OAI收割
来源：高能物理研究所
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