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Iron-induced generation of mitochondrial ROS depends on AMPK activity

文献类型：期刊论文

作者Hu Y(胡毅); Huang H(黄辉); Chen J(陈俊); Lu HR(卢会茹); Zhou MX(周梦雪); Chai ZF(柴之芳); Huang, H; Chen, J; Lu, HR; Zhou, MX
刊名BIOMETALS
出版日期2017
卷号30期号:4页码:623-628
关键词Fe(II) AMPK Neurotoxicity Mitochondria ROS
ISSN号0966-0844
DOI10.1007/s10534-017-0023-0
文献子类Article
英文摘要Deregulated iron homeostasis is generally believed to be implicated in neurodegenerative diseases, including Parkinson's disease. Nevertheless, it is not fully understood how iron overload can elicit neuronal cell damage. Here we examined mitochondrial reactive oxygen species (ROS) levels in human dopaminergic neuroblastoma SH-SY5Y cells upon iron exposure. A relatively high concentration of iron could significantly increase mitochondrial ROS levels in SH-SY5Y cells. Pharmacological activation of AMP-activated protein kinase (AMPK) almost completely inhibited the effect of iron on mitochondrial ROS. By contrast, AMPK inhibition aggravated the neurotoxicity of iron and enhanced the production of mitochondrial ROS. Collectively, these findings suggested that excess iron may be able to perturb mitochondrial function, and AMPK activity is important for the association of iron and mitochondria.
电子版国际标准刊号1572-8773
WOS关键词PARKINSONS-DISEASE ; SH-SY5Y CELLS ; NEUROTOXICITY ; STRESS ; MTOR ; DRUG
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000405780200014
源URL[http://ir.ihep.ac.cn/handle/311005/284953]  
专题高能物理研究所_多学科研究中心
高能物理研究所_实验物理中心
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714		 Hu Y,Huang H,Chen J,et al. Iron-induced generation of mitochondrial ROS depends on AMPK activity[J]. BIOMETALS,2017,30(4):623-628.
APA 胡毅.,黄辉.,陈俊.,卢会茹.,周梦雪.,...&Hu, Y.(2017).Iron-induced generation of mitochondrial ROS depends on AMPK activity.BIOMETALS,30(4),623-628.
MLA 胡毅,et al."Iron-induced generation of mitochondrial ROS depends on AMPK activity".BIOMETALS 30.4(2017):623-628.

入库方式： OAI收割

来源：高能物理研究所

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