Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials
文献类型：期刊论文
| 作者 | Yin, JJ; Jiang XM(江秀梅); Wang LM(王黎明) ; Tang JL(唐敬龙); Cao MJ(曹明晶); Chen CY(陈春英); Jiang, XM; Wang, LM; Ji, YL; Tang, JL
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| 刊名 | SMALL
 |
| 出版日期 | 2017 |
| 卷号 | 13期号:10页码:1602855 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201602855 |
| 文献子类 | Article |
| 英文摘要 | As a widely used nanomaterial in daily life, silver nanomaterials may cause great concern to female reproductive system as they are found to penetrate the bloodplacental barrier and gain access to the ovary. However, it is largely unknown about how silver nanomaterials influence ovarian physiology and functions such as hormone production. This study performs in vitro toxicology study of silver nanomaterials, focusing especially on cytotoxicity and steroidogenesis and explores their underlying mechanisms. This study exposes primary rat granulosa cells to gold nanorod core/silver shell nanostructures (Au@Ag NRs), and compares outcomes with cells exposed to gold nanorods. The Au@Ag NRs generate more reactive oxygen species and reduce mitochondrial membrane potential and less production of adenosine triphosphate. Au@Ag NRs promote steroidogenesis, including progesterone and estradiol, in a time-and dose-dependent manner. Chemical reactivity and transformation of Au@Ag NRs are then studied by electron spin resonance spectroscopy and X-ray absorption near edge structure, which analyze the generation of free radical and intracellular silver species. Results suggest that both particle-specific activity and intracellular silver ion release of Au@Ag NR contribute to the toxic response of granulosa cells. |
| 电子版国际标准刊号 | 1613-6829 |
| WOS关键词 | FOLLICLE-STIMULATING-HORMONE ; OXIDATIVE STRESS ; IN-VITRO ; GRANULOSA-CELLS ; CELLULAR UPTAKE ; ALLOY NANOPARTICLES ; EMBRYO DEVELOPMENT ; APOPTOSIS ; CYTOTOXICITY ; MECHANISM |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000397616200014 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/284958]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yin, JJ,Jiang XM,Wang LM,et al. Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials[J]. SMALL,2017,13(10):1602855. |
| APA | Yin, JJ.,江秀梅.,王黎明.,唐敬龙.,曹明晶.,...&Chen, CY.(2017).Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials.SMALL,13(10),1602855. |
| MLA | Yin, JJ,et al."Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials".SMALL 13.10(2017):1602855. |
入库方式： OAI收割
来源：高能物理研究所
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