Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response
文献类型：期刊论文
| 作者 | Zhang, CF; Zhao, YL ; Liu, XF; Zhang, GJ; Xie, JN; Dong, XH; Guo, Z; Du, JF; Gu, ZJ; Zhao YL(赵宇亮)
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| 刊名 | ACS NANO
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| 出版日期 | 2017 |
| 卷号 | 11期号:7页码:7164-7176 |
| 关键词 | polyoxometalates GdW10@CS nanosphere glutathione radiosensitization hypoxic tumor radiotherapy gene therapy |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.7b03037 |
| 文献子类 | Article |
| 英文摘要 | Radioresistance is one of the undesirable impediments in hypoxic tumors, which sharply diminishes the therapeutic effectiveness of radiotherapy and eventually results in the failure of their treatments. An attractive strategy for attenuating radioresistance is developing an ideal radiosensitization system with appreciable radiosensitization capacity to attenuate tumor hypoxia and reinforce radiotherapy response in hypoxic tumors. Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radio sensitization system for simultaneous extrinsic and intrinsic radiosensitization, by generating an overabundance of cytotoxic reactive oxygen species (ROS) using high-energy X-ray stimulation and mediating the hypoxia-inducible factor-la (HIF-la) siRNA to down-regulate HIF-la expression and suppress broken double-stranded DNA self-healing. Most importantly, the GdW10@CS nanospheres have the capacity to promote the exhaustion of intracellular glutathione (reduced GSH) by synergy W6+-triggered GSH oxidation for sufficient ROS generation, thereby facilitating the therapeutic efficiency of radiotherapy. As a result, the as-synthesized GdW10@CS nanosphere can overcome radioresistance of hypoxic tumors through a simultaneous extrinsic and intrinsic strategy to improve radiosensitivity. We have demonstrated GdW10@CS nanospheres with special radiosensitization behavior, which provides a versatile approach to solve the critical radioresistance issue of hypoxic tumors. |
| 电子版国际标准刊号 | 1936-086X |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; INDUCIBLE FACTOR-I ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; GOLD NANOPARTICLES ; TARGETING HYPOXIA ; GENE-EXPRESSION ; SIRNA DELIVERY ; QUANTUM DOTS ; RADIOTHERAPY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000406649700066 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/284983]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, CF,Zhao, YL,Liu, XF,et al. Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response[J]. ACS NANO,2017,11(7):7164-7176. |
| APA | Zhang, CF.,Zhao, YL.,Liu, XF.,Zhang, GJ.,Xie, JN.,...&雍媛.(2017).Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.ACS NANO,11(7),7164-7176. |
| MLA | Zhang, CF,et al."Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response".ACS NANO 11.7(2017):7164-7176. |
入库方式： OAI收割
来源：高能物理研究所
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