Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T-2-Weighted Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Zhang K(张凯) ; Wang YL(王亚玲); Xu C(徐超); Chang YN(常亚男); Zhao LN(赵丽娜); Zhao YL(赵宇亮); Gao FP(高福平); Gao XY(高学云); Wang, YL; Xu, C
|
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:34页码:28959-28966 |
| 关键词 | BSA biomineralization ultrasmall superparamagnetic iron oxide T-2-weighted magnetic resonance imaging |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b10030 |
| 文献子类 | Article |
| 英文摘要 | A facile method to synthesize ultrasmall-sized super magnetic iron Oxide nanoparticles with good monodispersity and high relaxivity is desired for magnetic resonance imaging (MRI) technology. Herein, we have developed a one-step method to direct the formation of superparamagnetic iron oxide nanoparticle (uBSPIO) using albumin under mild conditions. The resulting uBSPIO possess ultrasmall size (4.78 +/- 0.55 nm) and super high MR relaxivity (444.56 +/- 8.82 mM(-1) s(-1)). After grafted by the luteinizing hormone release hormone peptide (LHRH), the uBSPIO could targeted and accumulated in the tumor site. Finally, the uBSPIOs had good stability and did not induce cytotoxicity in vitro or major organ toxicity in vivo. The uBSPIOs are promising contrast agents for MRI. |
| WOS关键词 | MRI CONTRAST AGENTS ; BIOMEDICAL APPLICATIONS ; DRUG-DELIVERY ; CELLS ; TOMOGRAPHY ; RELAXIVITY ; THERAPY ; DESIGN ; NANOPROBES ; LHRH-PE40 |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000409395500090 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/284987]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_加速器中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhang K,Wang YL,Xu C,et al. Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T-2-Weighted Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(34):28959-28966. |
| APA | 张凯.,王亚玲.,徐超.,常亚男.,赵丽娜.,...&Gao, XY.(2017).Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T-2-Weighted Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,9(34),28959-28966. |
| MLA | 张凯,et al."Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T-2-Weighted Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 9.34(2017):28959-28966. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。