Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS
文献类型：期刊论文
| 作者 | Zhou MX(周梦雪); Yi Hu; Zhifang Chai ; Mengxue Zhou; Hu Y(胡毅); Huiru Lu; Jun Chen; Hui Huang; Huang H(黄辉); Chen J(陈俊)
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| 刊名 | BIOMETALS
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| 出版日期 | 2017 |
| 卷号 | 30期号:6页码:975-980 |
| 关键词 | mTOR Rapamycin Torin 1 ROS |
| ISSN号 | 0966-0844 |
| DOI | 10.1007/s10534-017-0059-1 |
| 文献子类 | Article |
| 英文摘要 | It is generally believed that gene-environment interaction may contribute to neurodegeneration. Of particular note is that iron overload may be one of the risk factors for neurodegeneration. However, the mechanisms underlying iron-associated neurotoxicity are not fully understood. Here we explored the effects of mechanistic target of rapamycin (mTOR) inhibition in iron-stressed human neuroblastoma cells. Two mTOR inhibitors, rapamycin and Torin 1, had similar effects in cells exposed to a relatively low concentration of iron. At a higher concentration of iron, Torin 1, instead of rapamycin, could further aggravate iron-induced cytotoxicity, and mitochondrial ROS levels were significantly higher in Torin 1-treated cells. These results suggest that mTOR inhibition may not be able to alleviate iron-induced neurotoxicity. |
| 电子版国际标准刊号 | 1572-8773 |
| WOS关键词 | PARKINSONS-DISEASE ; DIETARY-INTAKE ; SH-SY5Y CELLS ; RISK-FACTORS ; NEUROTOXICITY ; AUTOPHAGY ; COPPER |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000415283000012 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285076]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhou MX,Yi Hu,Zhifang Chai,et al. Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS[J]. BIOMETALS,2017,30(6):975-980. |
| APA | 周梦雪.,Yi Hu.,Zhifang Chai.,Mengxue Zhou.,胡毅.,...&柴之芳.(2017).Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.BIOMETALS,30(6),975-980. |
| MLA | 周梦雪,et al."Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS".BIOMETALS 30.6(2017):975-980. |
入库方式： OAI收割
来源：高能物理研究所
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