Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract
文献类型：期刊论文
| 作者 | Xing GM(刑更妹); Li M(李敏) ; Zhao YL(赵宇亮); Runcong Liu, Ya-Nan Chang, Gengmei Xing, Min Li and Yuliang Zhao; Chang YN(常亚男); Liu RC(刘润聪)
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| 刊名 | ROYAL SOCIETY OPEN SCIENCE
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| 出版日期 | 2017 |
| 卷号 | 4期号:11页码:170753 |
| 关键词 | oral delivery paclitaxel nanocrystal gastrointestinal tract |
| ISSN号 | 2054-5703 |
| DOI | 10.1098/rsos.170753 |
| 文献子类 | Article |
| 英文摘要 | Drug nanocrystals (NCs) can improve the solubility and bioavailability of insoluble drugs for oral administration. However, the biocompatibility and mechanisms of transmittance of drug NCs through the intestinal epithelial tissue are still not well understood. In this work, the physicochemical properties and interactions with biomolecules in oral delivery pathways, as well as the transmittance through mimical intestinal epithelial cells, of NCs of paclitaxel (PTX) are investigated. PTX was previously demonstrated to be an effective anti-cancer drug. It is found that maximum 1% (w/v) poly(styrenesulfonate) is sufficient to keep PTX NCs monodisperse in varied biological environments and presents no significant interaction with extracellular biomolecules for at least 24 h. The concentration of PTX NCs is kept carefully controlled to avoid serious toxicity to cells (10 mu gml(-1) in our experiments but this also depends on NC size). The transmittance of PTX NCs through mimical intestinal epithelial reached 25% in 6 h, demonstrating its comparatively high oral bioavailability in the human body. This work demonstrates the great potential of PTX NC treated in oral delivery. |
| WOS关键词 | POORLY SOLUBLE DRUGS ; CELL LUNG-CANCER ; INSULIN DELIVERY ; IN-VITRO ; NANOPARTICLES ; FORMULATION ; EFFICACY ; CHITOSAN ; COMBINATION ; MONOLAYERS |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000416787500020 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285101]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Xing GM,Li M,Zhao YL,et al. Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract[J]. ROYAL SOCIETY OPEN SCIENCE,2017,4(11):170753. |
| APA | 刑更妹,李敏,赵宇亮,Runcong Liu, Ya-Nan Chang, Gengmei Xing, Min Li and Yuliang Zhao,常亚男,&刘润聪.(2017).Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract.ROYAL SOCIETY OPEN SCIENCE,4(11),170753. |
| MLA | 刑更妹,et al."Study on orally delivered paclitaxel nanocrystals:modification,characterization and activity in the gastrointestinal tract".ROYAL SOCIETY OPEN SCIENCE 4.11(2017):170753. |
入库方式： OAI收割
来源：高能物理研究所
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