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Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine
文献类型：期刊论文
| 作者 | Zhu, ML ; Yuan, CX; Feng, SS; Gao ZQ(高增强); Gao, ZQ; Li, YH; Lu, LP
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| 刊名 | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学
 |
| 出版日期 | 2017 |
| 卷号 | 36期号:2页码:316-323 |
| ISSN号 | 0254-5861 |
| 关键词 | zinc(II) complex N-(4-hydroxybenzyl)-L-serine crystal structure inhibitory activity PTP1B TCPTP |
| DOI | 10.14102/j.cnki.0254-5861.2011-1355 |
| 文献子类 | Article |
| 英文摘要 | The reaction of the reduced Schiff base HL (N-(4-hydroxybenzyl)-L-serine) with Zn(CH3COO)(2)center dot 2H(2)O in aqueous solution afforded [Zn(L)(2)]center dot 3H(2)O (I). The complex has been characterized by elemental analysis, FT-IR, powder X-ray diffraction, electrospray ionization mass spectrometry and single-crystal X-ray diffraction. Complex I crystallizes in the orthorhombic system, space group P2(1)2(1)2(1), with a = 9.197(2), b = 10.445(2), c = 24.149(5) angstrom, V = 2319.8(8) angstrom(3), Z = 4, C20H30N2O11Zn, M-r = 539.83, D-c = 1.546 g.cm(3), mu = 1.122 mm(-1), F(000) = 1128, GOOF = 0.971, the final R = 0.0206 and wR = 0.0506 for 4346 observed reflections (I > 2 sigma(I)). In complex I, each Zn(II) ion coordinates with three carboxyl oxygen atoms and two amine nitrogen atoms from three L- anions, forming a distorted five-coordinated trigonal bipyramidal geometry. Complex I exhibits a 1D wavy chain structure that is extended by hydrogen-bonding interactions to form a supramolecular network. The bioactivity of the complex as a potential PTPs inhibitor in vitro was investigated, displaying potent inhibition against PTP1B (IC50, 0.24 mu M) and TCPTP (IC50, 0.53 mu M) with a moderate selectivity. |
| WOS关键词 | PROTEIN-TYROSINE PHOSPHATASES ; SCHIFF-BASE ; OXOVANADIUM(IV) COMPLEXES ; DERIVATIVES ; POTENT ; ACID ; 1B |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5924378 |
| WOS记录号 | WOS:000397985700018 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285188]  |
| 专题 | 高能物理研究所_核技术应用研究中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, ML,Yuan, CX,Feng, SS,et al. Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学,2017,36(2):316-323. |
| APA | Zhu, ML.,Yuan, CX.,Feng, SS.,高增强.,Gao, ZQ.,...&Lu, LP.(2017).Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学,36(2),316-323. |
| MLA | Zhu, ML,et al."Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(II) Complex with N-(4-hydroxybenzyl)-L-serine".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY结构化学 36.2(2017):316-323. |
入库方式： OAI收割
来源：高能物理研究所
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