Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects
文献类型：期刊论文
| 作者 | Liu, Y; Huang H(黄慧); Zhou MX(周梦雪); Lu HR(卢会茹); Chai ZF(柴之芳) ; Chen J(陈俊); Li, HP; Xie J(谢进); Hu Y(胡毅); Xie, J
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| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2017 |
| 卷号 | 5期号:5页码:1022-1031 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/c6bm00878j |
| 文献子类 | Article |
| 英文摘要 | Phototherapy, as a noninvasive therapeutic procedure, has been applied to treat tumors. However, the application of phototherapy is often compromised by its low efficiency. Herein, we developed a novel nanoplatform based on cationic amphiphilic polymer-wrapped carbon nanotubes (rPAA@SWCNTs) with a photosensitizer, indocyanine green (ICG), for phototherapy. The as-prepared nanoparticles exhibited excellent mitochondria targeting due to the synergistic properties of highly positive charges from the polycations on the corona and the high hydrophobicity from the carbon nanotubes in the core. Moreover, the high buffer capacity of the polycations facilitated the endosomal escape of nanoparticles via a proton-sponge effect. When irradiated with an 808 nm NIR laser, ICG/rPAA@SWCNTs could precisely damage mitochondria with high efficiency and produce reactive oxygen species (ROS) and hyperthermia, which further induced the ROS burst from damaged mitochondria. The overproduced ROS accumulated in mitochondria ultimately resulted in mitochondrial damage and cell death. Therefore ICG/rPAA@ SWCNTs may be able to achieve an amplifying phototherapeutic effect. |
| 电子版国际标准刊号 | 2047-4849 |
| WOS关键词 | WALLED CARBON NANOTUBES ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; DRUG-DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; CO-DELIVERY ; LIGHT ; CHEMOTHERAPY ; PHOTOSENSITIZER |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000400690700012 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285199]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Y,Huang H,Zhou MX,et al. Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects[J]. BIOMATERIALS SCIENCE,2017,5(5):1022-1031. |
| APA | Liu, Y.,黄慧.,周梦雪.,卢会茹.,柴之芳.,...&Hu, Y.(2017).Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects.BIOMATERIALS SCIENCE,5(5),1022-1031. |
| MLA | Liu, Y,et al."Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects".BIOMATERIALS SCIENCE 5.5(2017):1022-1031. |
入库方式： OAI收割
来源：高能物理研究所
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