Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells
文献类型：期刊论文
| 作者 | Wang YL(王亚玲) ; Wang, YL; Ma, XC; Li, YY; Zhang, ZL; Xiao, ZS; Liu, LJ; Gao, XY; Liu, J; Fang, X
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| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2017 |
| 卷号 | 5期号:22页码:4190-4197 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c7tb00422b |
| 文献子类 | Article |
| 英文摘要 | fRadiotherapy is an important technology for the clinical treatment of cancer, but the patients suffer from the severe side effects after exposure to radiation. There is an urgent need to develop theranostic agents with excellent imaging capability and effective radiosensitization in order to minimize X-ray irradiation. Herein, we report an approach to synthesize peptide-templated Au nanoclusters (AuNCs) for theranostic radiosensitization. A new peptide (CCYKFR) is designed for the preparation of AuNCs with uniform size distribution and fluorescence (656 nm) of high photostability. CCYKFR-AuNCs feature highly efficient targeting/accumulation on mitochondria after endocytosis. With a series of experiments, we demonstrate that CCYKFR-AuNCs irradiated by 4 Gy X-rays can introduce a burst of mitoROS and severe DNA damage leading to cancer cell death. This study presents an important strategy to design theranostic nanomaterials with improved radiosensitization for the development of new anti-cancer therapies. |
| 电子版国际标准刊号 | 2050-7518 |
| WOS关键词 | GOLD NANOPARTICLES ; X-RAY ; THERAPY ; RADIOTHERAPY ; DNA ; CLUSTERS ; MECHANISMS ; DAMAGE ; ROS ; RADIATION |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000403026400019 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285216]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_粒子天体物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang YL,Wang, YL,Ma, XC,et al. Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(22):4190-4197. |
| APA | 王亚玲.,Wang, YL.,Ma, XC.,Li, YY.,Zhang, ZL.,...&Fang, X.(2017).Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells.JOURNAL OF MATERIALS CHEMISTRY B,5(22),4190-4197. |
| MLA | 王亚玲,et al."Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells".JOURNAL OF MATERIALS CHEMISTRY B 5.22(2017):4190-4197. |
入库方式： OAI收割
来源：高能物理研究所
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