Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement
文献类型：期刊论文
| 作者 | Gu ZJ(谷战军) ; Li, B; Yan, L; Chen, CY; Gu, ZJ; Zhao, YL; Zhang, CY; Dong, XH; Yu, J; Yong, Y
|
| 刊名 | NANOSCALE
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:24页码:8229-8239 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c7nr02213a |
| 文献子类 | Article |
| 英文摘要 | Integrating radiation therapy with high-depth photothermal therapy in the second near-infrared (NIR) window is highly required for efficient treatment of deep-seated tumor cells. Here, we constructed a multifunctional nano-theranostic with bimetallic chalcogenide nanocrystals (NCs) functionalized with amphiphilic D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS-Cu3BiS3). Benefiting from the strong absorbance of both X-ray and NIR light in the second NIR window, TPGS-Cu3BiS3 CNs can not only deposit more radiation dose to trigger enhanced radiation damage in vivo, but also conduct photoinduced hyperthermia for thermal ablation in the second NIR window and effective improvement of tumor oxygenation to overcome the hypoxia-associated radio-resistance of tumors. Moreover, copper ions on the surface of TPGS-Cu3BiS3 NCs are capable of catalyzing the Fenton-like and Haber-Weiss reactions to produce highly reactive hydroxyl radicals, leading to the increase in the level of oxygen radicals and further enhance cancer cell destruction. Apart from their therapeutic application, by means of X-ray computer tomography imaging as well as multispectral optoacoustic tomography imaging, TPGS-Cu3BiS3 NCs also have the potential as a nano-theranostic to offer remarkable therapeutic outcome for deep-seated tumor cells in imaging-guided synergistically enhanced radiation therapy. |
| 电子版国际标准刊号 | 2040-3372 |
| WOS关键词 | GUIDED PHOTOTHERMAL THERAPY ; UP-CONVERSION NANOPARTICLES ; SURFACE-PLASMON RESONANCE ; BISMUTH SULFIDE NANORODS ; IN-VIVO ; SYNERGISTIC THERMORADIOTHERAPY ; GOLD NANOPARTICLES ; CATION-EXCHANGE ; DRUG-DELIVERY ; CANCER |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000403943600022 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285223]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gu ZJ,Li, B,Yan, L,et al. Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement[J]. NANOSCALE,2017,9(24):8229-8239. |
| APA | 谷战军.,Li, B.,Yan, L.,Chen, CY.,Gu, ZJ.,...&杜江锋.(2017).Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement.NANOSCALE,9(24),8229-8239. |
| MLA | 谷战军,et al."Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement".NANOSCALE 9.24(2017):8229-8239. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。