Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells
文献类型：期刊论文
| 作者 | Chen J(陈俊) ; Hu, Y; Chai, ZF; Yao, SQ; Zhu, Q; Zhou, MX; Huang, H; Chen, J; Lu, HR; Hu Y(胡毅)
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| 刊名 | BIOMETALS
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| 出版日期 | 2017 |
| 卷号 | 30期号:4页码:599-607 |
| 关键词 | Iron MAO-B Fluorescence probe |
| ISSN号 | 0966-0844 |
| DOI | 10.1007/s10534-017-0030-1 |
| 文献子类 | Article |
| 英文摘要 | Both monoamine oxidase B (MAO-B) and iron accumulation are associated with neurologic diseases including Parkinson's disease. However, the association of iron with MAO-B activity was poorly understood. Here we took advantage of highly sensitive and specific fluorescence probes to examine the change in MAO-B activity in human dopaminergic neuroblastoma (SH-SY5Y) cells upon iron exposure. Both ferric and ferrous ions could significantly enhance the activity of MAO-B, instead of MAO-A, in SH-SY5Y cells. In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent. These findings may suggest MAO-B is an important sensor in iron-stressed neuronal cells. |
| 电子版国际标准刊号 | 1572-8773 |
| WOS关键词 | PARKINSONS-DISEASE ; NEURODEGENERATIVE DISEASES ; INHIBITOR DRUGS ; BRAIN ; PROBE ; NEUROTOXICITY ; METAANALYSIS ; ANTIOXIDANT ; DERIVATIVES ; PREVENTION |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000405780200011 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285237]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen J,Hu, Y,Chai, ZF,et al. Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells[J]. BIOMETALS,2017,30(4):599-607. |
| APA | 陈俊.,Hu, Y.,Chai, ZF.,Yao, SQ.,Zhu, Q.,...&卢会茹.(2017).Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells.BIOMETALS,30(4),599-607. |
| MLA | 陈俊,et al."Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells".BIOMETALS 30.4(2017):599-607. |
入库方式： OAI收割
来源：高能物理研究所
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