Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation
文献类型：期刊论文
| 作者 | Geng H(耿会); Chang YN(常亚男) ; Bai X(白雪); Yuan Q(袁卿); Gu WH(古伟宏); Li J(李娟); Chen K(陈奎); Xing GM(邢更妹); Geng, H; Chang, YN
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| 刊名 | NANOSCALE
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:34页码:12516-12523 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c7nr04365a |
| 文献子类 | Article |
| 英文摘要 | Bone health requires regulation of homeostatic equilibrium between osteoblasts and osteoclasts. The over-activation of osteoclasts can disrupt bone metabolism, resulting in osteoporosis and other boneloss diseases. Fullerenol, a polyhydroxy derivative of fullerene, exhibits excellent biocompatibility. Here we show that fullerenol nanoparticles exert two functions: inhibition of osteoclastic differentiation and blockage of pre-osteoclast fusion to restructure osteoclast maturation and function. Experimentally, the nanoparticles reduced pre-osteoclast migration and inhibited ruffled border formation to block their maturation. In addition, fullerenol dose-dependently restricted the differentiation of bone marrow macrophage cells (BMMs) to form osteoclasts following treatment with macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor (NF)-kappa B (RANKL) to activate NF-kappa B and mitogen activating protein kinase (MAPK) signaling pathways. It is possible that the very small size of fullerenol allows it to directly cross the cellular membrane to access the cytoplasm and regulate osteoclastogenesis from BMMs. Our results suggest that fullerenol could be used to treat bone-loss diseases such as osteoporosis. |
| 电子版国际标准刊号 | 2040-3372 |
| WOS关键词 | ACTIN ; BONE ; MECHANISMS ; FUSION ; ORGANIZATION ; ACTIVATION ; PRECURSORS ; MIGRATION ; PODOSOME ; DISEASE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000409215300035 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285266]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_粒子天体物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Geng H,Chang YN,Bai X,et al. Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation[J]. NANOSCALE,2017,9(34):12516-12523. |
| APA | 耿会.,常亚男.,白雪.,袁卿.,古伟宏.,...&Xing, GM.(2017).Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation.NANOSCALE,9(34),12516-12523. |
| MLA | 耿会,et al."Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation".NANOSCALE 9.34(2017):12516-12523. |
入库方式： OAI收割
来源：高能物理研究所
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