Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues
文献类型：期刊论文
| 作者 | Du JF(杜江锋); Gu ZJ(谷战军) ; Yan L(晏亮); Yong Y(雍媛); Zhang X(张潇); Zhao YL(赵宇亮); Du, JF; Gu, ZJ; Yan, L; Yong, Y
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| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2017 |
| 卷号 | 29期号:34页码:1701268 |
| 关键词 | Bi2Se3 nanoparticles immunity radiation side-effects selenocysteine synergistic therapies |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201701268 |
| 文献子类 | Article |
| 英文摘要 | The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2Se3 nanoparicles (PVP-Bi2Se3@Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2Se3@Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2Se3@Sec NPs during the treatment, which demonstrates that PVP-Bi2Se3@Sec NPs have good biocompatibility. |
| 电子版国际标准刊号 | 1521-4095 |
| WOS关键词 | GUIDED PHOTOTHERMAL THERAPY ; MULTIFUNCTIONAL THERANOSTIC AGENT ; NEAR-INFRARED LIGHT ; RADIATION-THERAPY ; GOLD NANOPARTICLES ; X-RAY ; OXIDATIVE STRESS ; CATION-EXCHANGE ; CANCER-THERAPY ; HUMAN LIVER |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000409448300029 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285268]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Du JF,Gu ZJ,Yan L,et al. Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues[J]. ADVANCED MATERIALS,2017,29(34):1701268. |
| APA | 杜江锋.,谷战军.,晏亮.,雍媛.,张潇.,...&Zhao, YL.(2017).Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues.ADVANCED MATERIALS,29(34),1701268. |
| MLA | 杜江锋,et al."Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues".ADVANCED MATERIALS 29.34(2017):1701268. |
入库方式： OAI收割
来源：高能物理研究所
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