mTOR Signaling in Parkinson's Disease
文献类型：期刊论文
| 作者 | Chai, ZF ; Zhao, YL; Chen, J; Lan, AP; Hu Y(胡毅); Chai ZF(柴之芳); Zhao YL(赵宇亮); Chen J(陈俊); Lan AP(兰爱平); Hu, Y
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| 刊名 | NEUROMOLECULAR MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:1页码:1-10 |
| 关键词 | mTOR Parkinson's disease Apoptosis alpha-Synuclein Oxidative stress |
| ISSN号 | 1535-1084 |
| DOI | 10.1007/s12017-016-8417-7 |
| 文献子类 | Review |
| 英文摘要 | As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson's disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD. |
| 电子版国际标准刊号 | 1559-1174 |
| WOS关键词 | MUTANT ALPHA-SYNUCLEIN ; CENTRAL-NERVOUS-SYSTEM ; IN-VIVO MODELS ; OXIDATIVE STRESS ; DOPAMINERGIC-NEURONS ; MAMMALIAN TARGET ; NEURODEGENERATIVE DISEASES ; HYDROGEN-PEROXIDE ; PROTEIN-KINASE ; CELL-DEATH |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000396029500001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285385]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chai, ZF,Zhao, YL,Chen, J,et al. mTOR Signaling in Parkinson's Disease[J]. NEUROMOLECULAR MEDICINE,2017,19(1):1-10. |
| APA | Chai, ZF.,Zhao, YL.,Chen, J.,Lan, AP.,胡毅.,...&Hu, Y.(2017).mTOR Signaling in Parkinson's Disease.NEUROMOLECULAR MEDICINE,19(1),1-10. |
| MLA | Chai, ZF,et al."mTOR Signaling in Parkinson's Disease".NEUROMOLECULAR MEDICINE 19.1(2017):1-10. |
入库方式： OAI收割
来源：高能物理研究所
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