Resting-state brain alteration after a single dose of SSRI administration predicts 8-week remission of patients with major depressive disorder
文献类型：期刊论文
| 作者 | Bai, Y ; Xu, X; Xu, J; Arnone, D; Nie, B; Yu, H; Jiang, H; Dan BC(单保慈); Cheng, Y; Campbell, RAA
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| 刊名 | PSYCHOLOGICAL MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 47期号:3页码:438-450 |
| 关键词 | Escitalopram first-episode fractional amplitude of low-frequency fluctuation (fALFF) major depressive disorder neuroimaging remission resting-state fMRI |
| ISSN号 | 0033-2917 |
| DOI | 10.1017/S0033291716002440 |
| 文献子类 | Article |
| 英文摘要 | Background. The present study investigated alteration of brain resting-state activity induced by antidepressant treatment and attempted to investigate whether treatment efficacy can be predicted at an early stage of pharmacological treatment. Method. Forty-eight first-episode medication-free patients diagnosed with major depression received treatment with escitalopram. Resting-state functional magnetic resonance imaging was administered prior to treatment, 5 h after the first dose, during the course of pharmacological treatment (week 4) and at endpoint (week 8). Resting-state activity was evaluated in the course of the 8-week treatment and in relation to clinical improvement. Results. Escitalopram dynamically modified resting-state activity in depression during the treatment. After 5 h the antidepressant induced a significant decrease in the signal in the occipital cortex and an increase in the dorsolateral and dorsomedial prefrontal cortices and middle cingulate cortex. Furthermore, while remitters demonstrated more obvious changes following treatment, these were more modest in non-responders suggesting possible tonic and dynamic differences in the serotonergic system. Changes after 5 h in the caudate, occipital and temporal cortices were the best predictor of clinical remission at endpoint. Conclusions. This study revealed the possibility of using the measurement of resting-state neural changes a few hours after acute administration of antidepressant to identify individuals likely to remit after a few weeks of treatment. |
| 电子版国际标准刊号 | 1469-8978 |
| WOS关键词 | SEROTONIN REUPTAKE INHIBITOR ; LOW-FREQUENCY FLUCTUATION ; TREATMENT-RESISTANT DEPRESSION ; ANTERIOR CINGULATE CORTEX ; DEFAULT MODE NETWORK ; DRUG-NAIVE PATIENTS ; FUNCTIONAL CONNECTIVITY ; PHARMACOLOGICAL MRI ; EMOTION REGULATION ; SHORT-TERM |
| WOS研究方向 | Psychology ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000396303600005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285109]  |
| 专题 | 高能物理研究所_实验物理中心 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Bai, Y,Xu, X,Xu, J,et al. Resting-state brain alteration after a single dose of SSRI administration predicts 8-week remission of patients with major depressive disorder[J]. PSYCHOLOGICAL MEDICINE,2017,47(3):438-450. |
| APA | Bai, Y.,Xu, X.,Xu, J.,Arnone, D.,Nie, B.,...&聂彬彬.(2017).Resting-state brain alteration after a single dose of SSRI administration predicts 8-week remission of patients with major depressive disorder.PSYCHOLOGICAL MEDICINE,47(3),438-450. |
| MLA | Bai, Y,et al."Resting-state brain alteration after a single dose of SSRI administration predicts 8-week remission of patients with major depressive disorder".PSYCHOLOGICAL MEDICINE 47.3(2017):438-450. |
入库方式： OAI收割
来源：高能物理研究所
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