Diffusion characteristics of the fornix in patients with Alzheimer's disease
文献类型：期刊论文
| 作者 | Tang, SX; Dan BC(单保慈) ; Duan SF(段绍峰); Dai, JP; Shan, BC; Duan, SF; Wang, GH; Feng, QL
|
| 刊名 | PSYCHIATRY RESEARCH-NEUROIMAGING
 |
| 出版日期 | 2017 |
| 卷号 | 265页码:72-76 |
| 关键词 | Fornix Alzheimer's Disease Fractional anisotropy Mean diffusion |
| ISSN号 | 0925-4927 |
| DOI | 10.1016/j.pscychresns.2016.09.012 |
| 文献子类 | Article |
| 英文摘要 | White matter degradation is a major part of the pathogenesis of Alzheimer's disease (AD). The fornix is the predominant outflow tract from the hippocampus, and alterations to its microstructure in patients with AD are still being explored. Diffusion tensor imaging (DTI) is an in vivo neuroimaging technique that can provide unique information about alterations in tissue microstructure, which can indicate underlying neurobiological process at the microstructural level. In this prospective study, DTI was used to assess and analyze the microstructural features of the fornix in subjects with AD (n = 17), mild cognitive impairment (MCI; n = 12) and healthy controls (n = 17). DTI was performed using Explore DTI software and the FSL package. Within the fornix, patients with AD showed decreased fractional anisotropy values and length of fiber tracts of the fornix relative to healthy controls, but higher mean diffusivity values. MCI subjects showed a trend towards elevated mean diffusivity values in the fornix. The data suggest that DTI provides supporting information on the microstructural alteration of the fornix in patients with AD, and that these diffusion characteristics of the fornix may be helpful for the clinical diagnosis of AD. |
| 电子版国际标准刊号 | 1872-7506 |
| WOS关键词 | MILD COGNITIVE IMPAIRMENT ; WHITE-MATTER ; EPISODIC MEMORY ; MRI ; CONNECTIVITY ; TRACTOGRAPHY ; PROGRESSION ; DISRUPTION ; INTEGRITY ; PATHWAYS |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000405053200009 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285231]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Tang, SX,Dan BC,Duan SF,et al. Diffusion characteristics of the fornix in patients with Alzheimer's disease[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2017,265:72-76. |
| APA | Tang, SX.,单保慈.,段绍峰.,Dai, JP.,Shan, BC.,...&Feng, QL.(2017).Diffusion characteristics of the fornix in patients with Alzheimer's disease.PSYCHIATRY RESEARCH-NEUROIMAGING,265,72-76. |
| MLA | Tang, SX,et al."Diffusion characteristics of the fornix in patients with Alzheimer's disease".PSYCHIATRY RESEARCH-NEUROIMAGING 265(2017):72-76. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。