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Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity
文献类型：期刊论文
| 作者 | Li, YJ; Dan BC(单保慈) ; Shan, BC; Cui, CL; Wang, JK; Wang, BC; Xie, T; Yu, SS; Liang, SX; Wang, ZY
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| 刊名 | NEUROSCIENCE BULLETIN神经科学通报
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| 出版日期 | 2017 |
| 卷号 | 33期号:4页码:413-422 |
| 关键词 | Lateral thalamus Decisional impulsivity D1 receptor D2 receptor |
| ISSN号 | 1673-7067 |
| DOI | 10.1007/s12264-017-0146-x |
| 文献子类 | Article |
| 英文摘要 | The thalamus and central dopamine signaling have been shown to play important roles in high-level cognitive processes including impulsivity. However, little is known about the role of dopamine receptors in the thalamus in decisional impulsivity. In the present study, rats were tested using a delay discounting task and divided into three groups: high impulsivity (HI), medium impulsivity (MI), and low impulsivity (LI). Subsequent in vivo voxel-based magnetic resonance imaging revealed that the HI rats displayed a markedly reduced density of gray matter in the lateral thalamus compared with the LI rats. In the MI rats, the dopamine D1 receptor antagonist SCH23390 or the D2 receptor antagonist eticlopride was microinjected into the lateral thalamus. SCH23390 significantly decreased their choice of a large, delayed reward and increased their omission of lever presses. In contrast, eticlopride increased the choice of a large, delayed reward but had no effect on the omissions. Together, our results indicate that the lateral thalamus is involved in decisional impulsivity, and dopamine D1 and D2 receptors in the lateral thalamus have distinct effects on decisional impulsive behaviors in rats. These results provide a new insight into the dopamine signaling in the lateral thalamus in decisional impulsivity. |
| 电子版国际标准刊号 | 1995-8218 |
| WOS关键词 | REACTION-TIME-TASK ; D2 RECEPTORS ; ORBITOFRONTAL CORTEX ; NUCLEUS-ACCUMBENS ; ATTENTIONAL PERFORMANCE ; BASOLATERAL AMYGDALA ; RETICULAR NUCLEUS ; PRIMATE THALAMUS ; CHOICE ; MODULATION |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6045758 |
| WOS记录号 | WOS:000406345600006 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285242]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, YJ,Dan BC,Shan, BC,et al. Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity[J]. NEUROSCIENCE BULLETIN神经科学通报,2017,33(4):413-422. |
| APA | Li, YJ.,单保慈.,Shan, BC.,Cui, CL.,Wang, JK.,...&梁胜祥.(2017).Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity.NEUROSCIENCE BULLETIN神经科学通报,33(4),413-422. |
| MLA | Li, YJ,et al."Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity".NEUROSCIENCE BULLETIN神经科学通报 33.4(2017):413-422. |
入库方式： OAI收割
来源：高能物理研究所
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