Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture
文献类型：期刊论文
| 作者 | Tao, J; Zhang, YZ ; Liang, SX; Wu, J; Huang, J; Wang, ZF; Lin, RH; Chen, LD; Liang SX(梁胜祥); Liu, WL
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| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
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| 出版日期 | 2017 |
| 卷号 | 112页码:174-190 |
| 关键词 | Electroacupuncture Alzheimer's disease Glucose metabolism Cognitive impairment F-18-Fluoro-2-deoxy-D-Glucose Adenosine monophosphate-activated protein kinase AKT |
| ISSN号 | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2017.07.024 |
| 文献子类 | Article |
| 英文摘要 | An essential feature of Alzheimer's disease (AD) is implicated in brain energy metabolic impairment that is considered underlying pathogenesis of cognitive impairment. Therefore, therapeutic interventions to allay cognitive deficits that target energy metabolism may be an efficacy strategy in AD. In this study, we found that electroacupuncture (EA) at the DU20 acupoint obviously increased glucose metabolism in specific brain regions such as cortex, hippocampus, cingulate gyrus, basal forebrain septum, brain stem, and cerebellum in APP/PS1 transgenic mice by animal F-18-Fluoro-2-deoxy-D-Glucose (F-18-FDG)/positron emission tomography (PET) imaging, accompanied by cognitive improvements in the spatial reference learning and memory and memory flexibility and novel object recognition performances. Further evidence shown energy metabolism occurred in neurons or non-neuronal cells of the cortex and hippocampus in terms of the co-location of GLUT3/NeuN and GLUT1/GFAP. Simultaneously, metabolic homeostatic factors were critical for glucose metabolism, including phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and AKT serine/threonine kinase. Furthermore, EA-induced phosphorylated AMPK and AKT inhibited the phosphorylation level of the mammalian target of rapamycin (mTOR) to decrease the accumulation of amyloid-beta (A beta) in the cortex and hippocampus. These findings are concluded that EA is a potential therapeutic target for delaying memory decline and A beta deposition of AD. The AMPK and AKT are implicated in the EA-induced cortical and hippocampal energy metabolism, which served as a contributor to improving cognitive function and A beta deposition in a transgenic mouse model of AD. |
| 电子版国际标准刊号 | 1873-4596 |
| WOS关键词 | AMYLOID-BETA-PEPTIDE ; ALZHEIMERS-DISEASE ; MOUSE MODEL ; IMPROVES MEMORY ; AMPK ACTIVATION ; SAMP8 MICE ; HIPPOCAMPAL ; PATHWAY ; RATS ; ACUPUNCTURE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000411829300016 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/285280]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Tao, J,Zhang, YZ,Liang, SX,et al. Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture[J]. FREE RADICAL BIOLOGY AND MEDICINE,2017,112:174-190. |
| APA | Tao, J.,Zhang, YZ.,Liang, SX.,Wu, J.,Huang, J.,...&Lin, BB.(2017).Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture.FREE RADICAL BIOLOGY AND MEDICINE,112,174-190. |
| MLA | Tao, J,et al."Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture".FREE RADICAL BIOLOGY AND MEDICINE 112(2017):174-190. |
入库方式： OAI收割
来源：高能物理研究所
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