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Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection

文献类型：期刊论文

作者Li, Mo-Fei1,2; Sun, Li1,2
刊名DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
出版日期2018-02-01
卷号79页码:142-149
关键词Complement regulatory protein Complement activation Cynoglossus semilaevis Bacterial infection
ISSN号0145-305X
DOI10.1016/j.dci.2017.10.008
通讯作者Sun, Li(lsun@qdio.ac.cn)
英文摘要In mammals, membrane-associated complement regulatory proteins (MCRP) can protect host cells from the damaging of the activated complement. In teleost, few studies on the function of MCRP have been documented. In the present report, we identified a MCRP (named CsMCRP) from the teleost fish tongue sole Cynoglossus semilaevis and examined its immune function. CsMCRP shares moderate sequence identities with fish DAF-like molecules. CsMCRP was predicted to be a transmembrane protein with three short consensus repeats located in the extracellular region. CsMCRP expression occurred in nine different tissues, especially blood, and in peripheral blood leukocytes (PBL). Recombinant CsMCRP inhibited complement activation and interacted with bacterial pathogen, the latter in a highly selective manner. Antibody blocking the CsMCRP on PBL significantly inhibited bacterial infection of PBL. These results indicate that teleost CsMCRP is both a regulator of complement activation and a cellular receptor involved in bacterial invasion. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目National Natural Science Foundation of China[31330081] ; AoShan Talents Program ; Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province
WOS研究方向Fisheries ; Immunology ; Zoology
语种英语
WOS记录号WOS:000422811500016
出版者ELSEVIER SCI LTD
源URL[http://ir.qdio.ac.cn/handle/337002/157816]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Sun, Li
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Li, Mo-Fei,Sun, Li. Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,79:142-149.
APA Li, Mo-Fei,&Sun, Li.(2018).Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,79,142-149.
MLA Li, Mo-Fei,et al."Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 79(2018):142-149.

入库方式： OAI收割

来源：海洋研究所

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