中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
  4. 实验海洋生物学重点实验室
Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet

文献类型：期刊论文

作者Cai, Zhenyuan1,2; Wang, Liuyang3; Song, Xiaoying4; Tagore, Somnath5; Li, Xiangfeng2; Wang, Huihua6; Chen, Jiarui1,2; Li, Kexin6,7; Frenkel, Zeev7; Gao, Dahai8
刊名SCIENTIFIC REPORTS
出版日期2018-03-16
卷号8页码:11
ISSN号2045-2322
DOI10.1038/s41598-018-22483-7
通讯作者Frenkel-Morgenstern, Milana(milana.morgenstern@biu.ac.il) ; Zhang, Tongzuo(zhangtz@nwipb.cas.cn) ; Nevo, Eviatar(nevo@research.haifa.ac.il)
英文摘要Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes of zokors from three populations with distinct altitudes and ecologies (Low: 2846 m, Middle: 3282 m, High: 3,714 m) were sequenced and compared. Phylogenetic and principal component analyses classified them into three divergent altitudinal population clusters. Genetic polymorphisms showed that the population at H, approaching the uppermost species boundary, harbors the highest genetic polymorphism. Moreover, 1056 highly up-regulated UniGenes were identified from M to H. Gene ontologies reveal genes like EPAS1 and COX1 were overexpressed under hypoxia conditions. EPAS1, EGLN1, and COX1 were convergent in high-altitude adaptation against stresses in other species. The fixation indices (FST and GST)-based outlier analysis identified 191 and 211 genes, highly differentiated among L, M, and H. We observed adaptive transcriptome changes in Myospalax baileyi, across a few hundred meters, near the uppermost species boundary, regardless of their relatively stable underground burrows' microclimate. The highly variant genes identified in Myospalax were involved in hypoxia tolerance, hypercapnia tolerance, ATP-pathway energetics, and temperature changes.
资助项目National Natural Science Foundation of China[31370405] ; Key Technology Research and Development Program of Qinghai Province[2014-NS-113] ; CAS Key Technology Talent Program ; Ancell-Teicher Research Foundation for Genetics and Molecular Evolution ; Agricultural Science and Technology Innovation Program[CAAS-ASTIP-2016-IAR] ; VATAT ; VATAT[22351] ; Israel Cancer Association[204562]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000427585900005
出版者NATURE PUBLISHING GROUP
源URL[http://ir.qdio.ac.cn/handle/337002/158418]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Frenkel-Morgenstern, Milana; Zhang, Tongzuo; Nevo, Eviatar
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Qinghai, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27708 USA
4.Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China
5.Bar Ilan Univ, Azrieli Fac Med, IL-13195 Safed, Israel
6.Chinese Acad Sci, Inst Apicultural Res, Beijing 100093, Peoples R China
7.Univ Haifa, Inst Evolut, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel
8.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
9.Qinghai Prov Key Lab Anim Ecol Genom, Xining 810008, Qinghai, Peoples R China
推荐引用方式
GB/T 7714		 Cai, Zhenyuan,Wang, Liuyang,Song, Xiaoying,et al. Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet[J]. SCIENTIFIC REPORTS,2018,8:11.
APA Cai, Zhenyuan.,Wang, Liuyang.,Song, Xiaoying.,Tagore, Somnath.,Li, Xiangfeng.,...&Nevo, Eviatar.(2018).Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet.SCIENTIFIC REPORTS,8,11.
MLA Cai, Zhenyuan,et al."Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet".SCIENTIFIC REPORTS 8(2018):11.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。