Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway
文献类型：期刊论文
| 作者 | Liu, Yingjuan1,2,3 ; Geng, Lihua1,2,3; Zhang, Jingjing4; Wang, Jing1,2; Zhang, Qi1,2,3; Duan, Delin2,5; Zhang, Quanbin1,2
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2018-03-01 |
| 卷号 | 16期号:3页码:16 |
| 关键词 | oligo-porphyran PI3K/Akt apoptosis Parkinson's disease neurobehavior |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md16030082 |
| 英文摘要 | Parkinson's disease (PD) is a neurodegenerative movement disorder that is caused by a selective loss of dopaminergic neurons. Current PD treatments provide symptomatic relief but do not prevent or decelerate disease progression. Previous studies have suggested that acetylated and phosphorylated porphyran, derived from Porphyra, produces a neuroprotective effect against 6-OHDA-induced damage. Due to its antioxidant and neuroprotective potential, this study evaluates whether oligo-porphyran (OP) could be beneficial in an experimental model of PD in mice. The drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was intraperitoneally injected (20 mg/kg body weight) for seven days to simulate PD, followed by OP administration. We found that the behavioral deficits in spontaneous motor activity, latency to descend in a pole test, and suspension in a traction test were ameliorated, and excessive dopamine (DA) metabolism was suppressed after OP treatment. Additionally, we found that OP protected dopaminergic neurons by preventing MPTP-induced decreases in dopaminergic transporter and tyrosine hydroxylase protein levels. We speculated whether OP regulates a signaling pathway that affects the behavioral changes seen in PD mice. In this study, the PI3K/Akt/Bcl-2 pathway was detected. Our results demonstrate that OP increased the phosphorylation of PI3K/Akt/GSK-3 beta and inhibited the activation of caspase-3 and poly (ADP-ribose) polymerase, with changes in the Bax/Bcl-2 ratio. These results showed thatOPmight promote DA neuron survival in vivo by regulating the PI3K/Akt/Bcl-2 pathway, thereby ameliorating the neurobehavioral deficits in a PD mouse model and suggesting OP as a neuroprotective treatment for PD. |
| 资助项目 | Youth Innovation Promotion Association of CAS[2016190] ; Evaluation and Transformation of Active Natural Compounds ; Strategic Biological Resources Service Network Programme[ZSTH-025] ; Fujian STS Programme of Chinese Academy of Sciences ; Science and Technology project of Fujian Province[2017T3015] ; Jiangsu Science & Technology Project[BE2015335] ; Jiangsu Innovative & Entrepreneurial Talents Project ; Science and Technology Project of Shandong Province[2016GSF115031] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000428510200008 |
| 出版者 | MDPI |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/159198]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhang, Quanbin |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Eighth Peoples Hosp, Pharmaceut Dept, Qingdao 266000, Peoples R China 5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yingjuan,Geng, Lihua,Zhang, Jingjing,et al. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway[J]. MARINE DRUGS,2018,16(3):16. |
| APA | Liu, Yingjuan.,Geng, Lihua.,Zhang, Jingjing.,Wang, Jing.,Zhang, Qi.,...&Zhang, Quanbin.(2018).Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway.MARINE DRUGS,16(3),16. |
| MLA | Liu, Yingjuan,et al."Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway".MARINE DRUGS 16.3(2018):16. |
入库方式： OAI收割
来源：海洋研究所
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