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Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa

文献类型：期刊论文

作者Sun, Yuhao1,2,3,4; Chen, Xiaolin1,2,4; Song, Lin5; Liu, Song1,2,4; Yu, Huahua1,2,4; Wang, Xueqin1,2,4; Qin, Yukun1,2,4; Li, Pengcheng1,2,4
刊名BIOMED RESEARCH INTERNATIONAL
出版日期2018
页码11
ISSN号2314-6133
DOI10.1155/2018/9415965
通讯作者Chen, Xiaolin(chenxl@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要Avian Leukosis Virus Subgroup J (ALV-J), a retrovirus of avian, has caused enormous economics losses to poultry industry around the world. Polysaccharides from marine algae are featured diversity bioactivities. To find the potential effect to prevent ALV-J spread, in this study, polysaccharides from Ulva pertusa (UPPs) and four low molecular weight (Mw) U. pertusa polysaccharides (LUPPs) were prepared and their functions on ALV-J were investigated. Firstly, LUP Ps were obtained by hydrogen peroxide (H2O2) oxidative degradation. The effects of degradation conditions on Mw of the UPP were also investigated. Results showed that the H2O2 oxidative degradation method could degrade UPP effectively, and the degradation was positively related to H2O, concentration and temperature and negatively to pH. The chemical characteristics of UPP and LUPPs were also determined. Afterwards, the anti-ALVJ activity of the polysaccharides were carried out in vitro. Results showed that UPP and LUPPs could inhibit ALV-J and LUPP-3 and Mw of 4.3 ki)a exerted the strongest suppression. The action phase assay showed that LUPP-3 could bind with the viral particles and prevented ALV-J adsorption onto the host cells. And the ALV-J relative gene and gp85 protein expression were significantly suppressed after being administration with LUPP-3. Therefore, the low Mw polysaccharides from U. pertusa have great potential as an anti-ALV-J drug alternative.
资助项目Shandong Province Key Research and Development Project[2016YYSP010] ; NSFC-Shandong Joint Fund[U1606403] ; Qingdao People's Livelihood Science and Technology Projects[16-6-2-41-nsh]
WOS研究方向Biotechnology & Applied Microbiology ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000442101000001
出版者HINDAWI LTD
源URL[http://ir.qdio.ac.cn/handle/337002/159870]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Chen, Xiaolin; Li, Pengcheng
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
5.Qingdao Univ Sci & Technol, Coll Marine Sci & Biol Engn, Qingdao 266042, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Yuhao,Chen, Xiaolin,Song, Lin,et al. Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa[J]. BIOMED RESEARCH INTERNATIONAL,2018:11.
APA Sun, Yuhao.,Chen, Xiaolin.,Song, Lin.,Liu, Song.,Yu, Huahua.,...&Li, Pengcheng.(2018).Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa.BIOMED RESEARCH INTERNATIONAL,11.
MLA Sun, Yuhao,et al."Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa".BIOMED RESEARCH INTERNATIONAL (2018):11.

入库方式： OAI收割

来源：海洋研究所

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