Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22
文献类型：期刊论文
| 作者 | Li, Yi-qun1,2,3,4; Sun, Li1,2,3; Li, Jun2,3,5 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 84页码:138-147 |
| 关键词 | Paralichthys olivaceus IgM(+) B cells Endocytosis Macropinocytosis CD22 B cell regulation |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2018.09.068 |
| 通讯作者 | Sun, Li(lsun@qdio.ac.cn) ; Li, Jun(jli@lssu.edu) |
| 英文摘要 | B cells in fish are proven to be endocytic and have a great contribution to innate immunity like phagocytosis. In this study, the endocytic capacity and the corresponding internalization pathways of IgM(+) B cells in Japanese flounder (Paralichthys olivaceus) were investigated. The results showed that IgM(+) B cells in peripheral blood leukocytes (PBL) and splenic leukocytes (SL) exhibited different abilities to ingest 0.5 mu m and 1 pm latex beads through macropinocytosis-dependent endocytic pathway. Japanese flounder CD22 (PoCD22) co-stimulatory signals were identified to be essential for the innate immune responses in B cells. Most of IgM+ B cells and some IgM(-) cells were demonstrated to be PoCD22 positive. When PoCD22 was blocked by antibody, the endocytic activities and reactive oxygen species (ROS) activities of SL IgM(+) B cells were significantly increased, while the endocytic and ROS activities of PBL IgM(+) B cells were significant decreased. These results collectively suggest that Japanese flounder IgM(+) B cells are able to employ macropinocytosis-dependent endocytic pathway, which is under the regulation of CD22. |
| 资助项目 | National Natural Science Foundation of China[31528019] ; AoShan Talents Program from Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000457666800017 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/160825]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Li; Li, Jun |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Lake Super State Univ, Sch Biol Sci, 650 W Easterday Ave, Sault Ste Marie, MI 49783 USA |
| 推荐引用方式 GB/T 7714 | Li, Yi-qun,Sun, Li,Li, Jun. Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22[J]. FISH & SHELLFISH IMMUNOLOGY,2019,84:138-147. |
| APA | Li, Yi-qun,Sun, Li,&Li, Jun.(2019).Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22.FISH & SHELLFISH IMMUNOLOGY,84,138-147. |
| MLA | Li, Yi-qun,et al."Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22".FISH & SHELLFISH IMMUNOLOGY 84(2019):138-147. |
入库方式： OAI收割
来源：海洋研究所
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