CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs
文献类型：期刊论文
| 作者 | Luo, Jiao1,2; Jiang, Bo2; Li, Chao2; Jia, Xiaoling2; Shi, Dayong3 |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2019 |
| 卷号 | 17期号:1页码:15 |
| ISSN号 | 1660-3397 |
| 关键词 | brominated organic compounds hypoglycemic activity insulin-sensitizing effect RBPs RNA splicing |
| DOI | 10.3390/md17010049 |
| 通讯作者 | Shi, Dayong(shidayong@sdu.edu.cn) |
| 英文摘要 | RNA-binding proteins (RBPs) lie at the center of posttranscriptional regulation and the dysregulation of RBPs contributes to diabetes. Therefore, the modulation of RBPs is anticipated to become a potential therapeutic approach to diabetes. CYC27 is a synthetic derivative of marine bromophenol BDB, which is isolated from red alga Rhodomela confervoides. In this study, we found that CYC27 significantly lowered the blood glucose levels of diabetic BKS db mice. Moreover, CYC27 effectively ameliorated dyslipidemia in BKS db mice by reducing their total serum cholesterol (TC) and triglyceride (TG) levels. Furthermore, CYC27 was an insulin-sensitizing agent with increased insulin-stimulated phosphorylation of insulin receptors and relevant downstream factors. Finally, to systemically study the mechanisms of CYC27, label-free quantitative phosphoproteomic analysis was performed to investigate global changes in phosphorylation. Enriched GO annotation showed that most regulated phosphoproteins were related to RNA splicing and RNA processing. Enriched KEGG analysis showed that a spliceosome-associated pathway was the predominant pathway after CYC27 treatment. Protein-protein interaction (PPI) analysis showed that CYC27 modulated the process of mRNA splicing via phosphorylation of the relevant RBPs, including upregulated Cstf3 and Srrt. Our results suggested that CYC27 treatment exerted promising anti-diabetic effects by sensitizing the insulin signaling pathways and modulating RNA splicing-associated RBPs. |
| 资助项目 | Key Research and Development Project of the Shandong Province[2018GSF118208] ; Key Research and Development Project of the Shandong Province[2016ZDJS07A13] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; National Program for Support of Top-notch Young Professionals ; Fund of Taishan Scholar Project ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; NSFC-Shandong Joint Fund[U1706213] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-1-1] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-3-9] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000458053200049 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/160870]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Shi, Dayong |
| 作者单位 | 1.Qingdao Univ, Sch Publ Hlth, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Jiao,Jiang, Bo,Li, Chao,et al. CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs[J]. MARINE DRUGS,2019,17(1):15. |
| APA | Luo, Jiao,Jiang, Bo,Li, Chao,Jia, Xiaoling,&Shi, Dayong.(2019).CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs.MARINE DRUGS,17(1),15. |
| MLA | Luo, Jiao,et al."CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs".MARINE DRUGS 17.1(2019):15. |
入库方式： OAI收割
来源：海洋研究所
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