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Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom

文献类型：期刊论文

作者Li, Aoyu1,2,3,4; Yu, Huahua1,2,3; Li, Rongfeng1,2,3; Liu, Song1,2,3; Xing, Ronge1,2,3; Li, Pengcheng1,2,3
刊名TOXINS
出版日期2019-03-10
卷号11期号:3页码:12
关键词Nemopilema nomurai nematocyst venom (NnNV) jellyfish dermatitis matrix metalloproteinases (MMPs) inflammatory factors skin cells
ISSN号2072-6651
DOI10.3390/toxins11030156
通讯作者Yu, Huahua(yuhuahua@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要Jellyfish envenomations result in extensive dermatological symptoms, clinically named as jellyfish dermatitis, which can seriously affect the daily activities and physical health of people. Inflammatory response accompanies the whole process of jellyfish dermatitis and the complexity of jellyfish venom components makes it difficult to treat jellyfish dermatitis symptoms effectively. Moreover, inhibiting inflammation is essential for the treatment of jellyfish stings and exploring the main components of jellyfish venom that cause inflammation is an urgent research area. In this study, the inhibitory effects of matrix metalloproteinase (MMP) inhibitors for venom-induced inflammation were explored at a cellular level. The expression of the three inflammatory factors, IL-6, TNF-alpha and MCP-1 in two skin cell lines, human keratinocyte cells (HaCaT) and human embryonic skin fibroblasts cells (CCC-ESF-1), at the cellular level, after treatment with the inhibitors of jellyfish Nemopilema nomurai (N. nomurai) nematocyst venom (NnNV-I), were determined. The results showed that inhibitors of MMP can significantly reduce the toxic effects of jellyfish Nemopilema nomurai nematocyst venom (NnNV) to skin cells. The expression levels of the three inflammatory factors IL-6, MCP-1, and TNF-alpha in the cells were also significantly decreased, indicating that MMPs in jellyfish venom are probably vital factors leading to jellyfish dermatitis. This study is beneficial in the prevention and treatment of jellyfish stings.
资助项目National Natural Science Foundation of China[41776163] ; National Key RD Plan[2017YFE0111100-04] ; Key Research and Development Plan of Shandong Province[2017GHY215003] ; Qingdao Science and Technology Project[17-3-3-21-nsh]
WOS研究方向Food Science & Technology ; Toxicology
语种英语
WOS记录号WOS:000464475100001
出版者MDPI
源URL[http://ir.qdio.ac.cn/handle/337002/161164]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Yu, Huahua; Li, Pengcheng
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom[J]. TOXINS,2019,11(3):12.
APA Li, Aoyu,Yu, Huahua,Li, Rongfeng,Liu, Song,Xing, Ronge,&Li, Pengcheng.(2019).Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom.TOXINS,11(3),12.
MLA Li, Aoyu,et al."Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom".TOXINS 11.3(2019):12.

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来源：海洋研究所

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