Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway
文献类型：期刊论文
| 作者 | Xu, Kuo1; Guo, Chuanlong1,2 ; Meng, Jie1,3; Tian, Haiying4; Guo, Shuju1; Shi, Dayong1,5
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| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2019-04-01 |
| 卷号 | 17期号:4页码:11 |
| 关键词 | Aspergillus naphthopyrones cytotoxicity endophytic fungus Leathesia nana |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md17040207 |
| 通讯作者 | Guo, Shuju(guoshuju@qdio.ac.cn) ; Shi, Dayong(shidayong@qdio.ac.cn) |
| 英文摘要 | A study on the secondary metabolites of Aspergillus sp. XNM-4, which was derived from marine algae Leathesia nana (Chordariaceae), led to the identification of one previously undescribed (1) and seventeen known compounds (2-18). Their planar structures were established by extensive spectroscopic analyses, while the stereochemical assignments were defined by electronic circular dichroism (ECD) calculations. The biological activities of the compounds were assessed on five human cancer cell lines (PANC-1, A549, MDA-MB-231, Caco-2, and SK-OV-3), and one human normal cell line (HL-7702) using an MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide] assay. Among them, the dimeric naphthopyrones 7, 10 and 12 exhibited potent cytotoxicity. Further mechanism studies showed that 12 induced apoptosis, arrested the cell cycle at the G0/G1 phase in the PANC-1 cells, caused morphological changes and generated ROS; and it induces PANC-1 cells apoptosis via ROS-mediated PI3K/Akt signaling pathway. |
| 资助项目 | National Natural Science Foundation of China[81803375] ; National Postdoctoral Program for Innovative Talents[BX201700247] ; China Postdoctoral Science Foundation[2018M630804] ; Natural Science Foundation of Shandong Province[ZR2016DQ07] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000467307100014 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/161355]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Guo, Shuju; Shi, Dayong |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Shandong, Peoples R China 3.Qingdao Agr Univ, Coll Resources & Environm, Qingdao 266109, Shandong, Peoples R China 4.China Tobacco Henan Ind Co Ltd, Technol Ctr, Zhengzhou 450000, Henan, Peoples R China 5.Shandong Univ, Sch Life Sci, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Kuo,Guo, Chuanlong,Meng, Jie,et al. Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway[J]. MARINE DRUGS,2019,17(4):11. |
| APA | Xu, Kuo,Guo, Chuanlong,Meng, Jie,Tian, Haiying,Guo, Shuju,&Shi, Dayong.(2019).Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway.MARINE DRUGS,17(4),11. |
| MLA | Xu, Kuo,et al."Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway".MARINE DRUGS 17.4(2019):11. |
入库方式： OAI收割
来源：海洋研究所
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