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A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei

文献类型：期刊论文

作者Wang, Quanchao1; Yu, Yang1,2; Zhang, Qian1,3; Zhang, Xiaojun1,2; Yuan, Jianbo1,2; Huang, Hao4; Xiang, Jianhai1,2,5; Li, Fuhua1,2,5
刊名FRONTIERS IN GENETICS
出版日期2019-05-31
卷号10页码:8
关键词penaeid shrimp growth traits GWAS candidate gene class C scavenger receptor
ISSN号1664-8021
DOI10.3389/fgene.2019.00520
通讯作者Li, Fuhua(fhli@qdio.ac.cn)
英文摘要Improvements of growth traits are always the focus in selective breeding programs for the Pacific white shrimp Litopenaeus vannamei (L. vannamei). Identification of growth-related genes or markers can contribute to the application of modern breeding technologies, and thus accelerate the genetic improvement of growth traits. The aim of this study was to identify the genes and molecular markers associated with the growth traits of L. vannamei. A population of 200 individuals was genotyped using 2b-RAD techniques for genome-wide linkage disequilibrium (LD) analysis and genome-wide association study (GWAS). The results showed that the LD decayed fast in the studied population, which suggest that it is feasible to fine map the growth-related genes with GWAS in L. vannamei. One gene designated as LvSRC, encoding the class C scavenger receptor (SRC), was identified as a growth-related candidate gene by GWAS. Further targeted sequencing of the candidate gene in another population of 322 shrimps revealed that several non-synonymous mutations within LvSRC were significantly associated with the body weight (P < 0.01), and the most significant marker (SRC_24) located in the candidate gene could explain 13% of phenotypic variance. The current results provide not only molecular markers for genetic improvement in L. vannamei, but also new insights for understanding the growth regulation mechanism in penaeid shrimp.
资助项目National Key R&D Program of China[2018YFD0901301] ; National Natural Science Foundation of China[31830100] ; China Agriculture Research System-48 (CARS-48)
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000470234400001
出版者FRONTIERS MEDIA SA
源URL[http://ir.qdio.ac.cn/handle/337002/161559]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Li, Fuhua
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Hainan Grand Suntop Ocean Breeding Co Ltd, Wenchang, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Quanchao,Yu, Yang,Zhang, Qian,et al. A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei[J]. FRONTIERS IN GENETICS,2019,10:8.
APA Wang, Quanchao.,Yu, Yang.,Zhang, Qian.,Zhang, Xiaojun.,Yuan, Jianbo.,...&Li, Fuhua.(2019).A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei.FRONTIERS IN GENETICS,10,8.
MLA Wang, Quanchao,et al."A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei".FRONTIERS IN GENETICS 10(2019):8.

入库方式： OAI收割

来源：海洋研究所

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