Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides
文献类型：期刊论文
| 作者 | Zhang, Fan-Zhong1,2,3 ; Li, Xiao-Ming1,2; Li, Xin1,2; Yang, Sui-Qun1,2; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,3
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2019-05-01 |
| 卷号 | 17期号:5页码:13 |
| 关键词 | mangrove plant endophytic fungus Cladosporium cladosporioides polyketides antimicrobial activity acetylcholinesterase enzymatic inhibitory activity |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md17050296 |
| 通讯作者 | Meng, Ling-Hong(m8545303@163.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Five new polyketides, namely, 5R-hydroxyrecifeiolide (1), 5S-hydroxyrecifeiolide (2), ent-cladospolide F (3), cladospolide G (4), and cladospolide H (5), along with two known compounds (6 and 7), were isolated from the endophytic fungal strain Cladosporium cladosporioides MA-299 that was obtained from the leaves of the mangrove plant Bruguiera gymnorrhiza. The structures of these compounds were established by extensive analysis of 1D/2D NMR data, mass spectrometric data, ECDs and optical rotations, and modified Mosher's method. The structures of 3 and 6 were confirmed by single-crystal X-ray diffraction analysis and this is the first time for reporting the crystal structures of these two compounds. All of the isolated compounds were examined for antimicrobial activities against human and aquatic bacteria and plant pathogenic fungi as well as enzymatic inhibitory activities against acetylcholinesterase. Compounds 1-4, 6, and 7 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 1.0 to 64 g/mL, while 3 exhibited enzymatic inhibitory activity against acetylcholinesterase with the IC50 value of 40.26 M. |
| 资助项目 | Natural Science Foundation of China[81673351] ; Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province, China[ZR2016BQ17] ; Taishan Scholar project from Shandong province |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000470964600049 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/161819]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,et al. Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides[J]. MARINE DRUGS,2019,17(5):13. |
| APA | Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2019).Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides.MARINE DRUGS,17(5),13. |
| MLA | Zhang, Fan-Zhong,et al."Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides".MARINE DRUGS 17.5(2019):13. |
入库方式： OAI收割
来源：海洋研究所
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