Staphylococcal enterotoxin C2 as an adjuvant for rabies vaccine induces specific immune responses in mice
文献类型：期刊论文
| 作者 | Yao, Songyuan1,2; Li, Yongqiang1,2; Zhang, Qianru1; Zhang, Huiwen1; Zhou, Libao3; Liao, Hui3; Zhang, Chenggang1; Xu, Mingkai1 |
| 刊名 | PATHOGENS AND DISEASE
 |
| 出版日期 | 2018-07-01 |
| 卷号 | 76期号:5 |
| 关键词 | Adjuvant Rabies Vaccine Sec2 |
| ISSN号 | 2049-632X |
| DOI | 10.1093/femspd/fty049 |
| 英文摘要 | Rabies vaccine administration is the most effective method to prevent the occurrence of rabies disease. However, administration of rabies vaccine without adjuvant always shows low efficiency. As a member of superantigen, staphylococcal enterotoxin C2 (SEC2) non-specifically activates T-cells at extremely low concentration. It enlightens us that SEC2 may be used as an adjuvant. We carried out the experiment that the mice received twice immunization with rabies vaccine in the presence or absence of SEC2 at 1-week interval. Serum and splenocytes from immunized mice were collected to measure the level of rabies-specific-IgG and the cell that secretes IFN-gamma or IL-4. The promotion of antigen-specific splenocytes proliferation was also detected. Besides, a challenge test was performed to evaluate the protective efficiency of SEC2. It was shown that mice immunized with vaccine combined with SEC2 generated more specific anti-rabies-antibodies. The results for production of IFN-gamma and IL-4, as well as the proliferation of splenocytes from immunized mice indicated SEC2 promoted the specific immune responses induced by rabies vaccine. Moreover, immunization of mice with vaccine combined with SEC2 provided efficient protection against the lethal rabies exposure. Taken together, our findings indicated that SEC2 can be served as an adjuvant for rabies vaccines. |
| WOS研究方向 | Immunology ; Infectious Diseases ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000441740900006 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://210.72.129.5/handle/321005/121219]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Xu, Mingkai |
| 作者单位 | 1.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chengda Biotechnol Co Ltd, Shenyang 110179, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Songyuan,Li, Yongqiang,Zhang, Qianru,et al. Staphylococcal enterotoxin C2 as an adjuvant for rabies vaccine induces specific immune responses in mice[J]. PATHOGENS AND DISEASE,2018,76(5). |
| APA | Yao, Songyuan.,Li, Yongqiang.,Zhang, Qianru.,Zhang, Huiwen.,Zhou, Libao.,...&Xu, Mingkai.(2018).Staphylococcal enterotoxin C2 as an adjuvant for rabies vaccine induces specific immune responses in mice.PATHOGENS AND DISEASE,76(5). |
| MLA | Yao, Songyuan,et al."Staphylococcal enterotoxin C2 as an adjuvant for rabies vaccine induces specific immune responses in mice".PATHOGENS AND DISEASE 76.5(2018). |
入库方式： OAI收割
来源：沈阳应用生态研究所
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