Toxic effects of chlorpromazine on Carassius auratus and its oxidative stress
文献类型：期刊论文
| 作者 | Li, Ting; Zhou, Qixing1,2; Zhang, Ning; Luo, Yi |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:8页码:638-643 |
| 关键词 | Chlorpromazine Goldfish Carassius Auratus Toxic Effect Oxidative Stress |
| ISSN号 | 0360-1234 |
| DOI | 10.1080/03601230802352674 |
| 英文摘要 | Under laboratory conditions, ecotoxicological effects of chlorpromazine (CPZ) on freshwater goldfish (Carassius auratus) were examined using the toxic culture experiment. The results showed that the median lethal concentration (LC(50)) of CPZ toxic to Carassius auratus in 24, 48 and 96 h was 1.11, 0.43 and 0.32 mg/L, respectively. Thus, CPZ is an extreme toxicant to goldfish. Furthermore, there were significantly positive correlations between the ecotoxicological effects of CPZ and its concentrations, and the toxicity became higher as the exposure time increased. The activity of superoxide dismutase (SOD) and catalase (CAT) in goldfish livers was significantly influenced by CPZ. At the same exposure time, the activity of SOD reduced first, and increased then, whereas the activity of CAT enhanced first and decreased then. At the same exposure levels of CPZ, the activity of SOD and CAT changed similarly, decreased first, then increased and decreased at last. Within the range of exposure concentrations, the changes in the activity of CAT can more easily reflect the oxidation stress in Carassius auratus by CPZ than those of SOD. |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000260229800002 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://210.72.129.5/handle/321005/121309]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Zhou, Qixing |
| 作者单位 | 1.Nankai Univ, Coll Environm Sci & Engn, Minist Educ, Key Lab Pollut Proc & Environm Criteria, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, Key Lab Terr Ecol Proc, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ting,Zhou, Qixing,Zhang, Ning,et al. Toxic effects of chlorpromazine on Carassius auratus and its oxidative stress[J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES,2008,43(8):638-643. |
| APA | Li, Ting,Zhou, Qixing,Zhang, Ning,&Luo, Yi.(2008).Toxic effects of chlorpromazine on Carassius auratus and its oxidative stress.JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES,43(8),638-643. |
| MLA | Li, Ting,et al."Toxic effects of chlorpromazine on Carassius auratus and its oxidative stress".JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES 43.8(2008):638-643. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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