Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production
文献类型：期刊论文
| 作者 | Zheng, Weifa3; Miao, Kangjie3; Liu, Yubing1,3; Zhao, Yanxia3; Zhang, Meimei3; Pan, Shenyuan1; Dai, Yucheng2 |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 87期号:4页码:1237-1254 |
| 关键词 | Inonotus Obliquus Bioactive Metabolites Submerged Cultures Biosynthetic Pathways Signal Transduction S-nitrosylation Nmr-based Metabonomic Analysis |
| ISSN号 | 0175-7598 |
| DOI | 10.1007/s00253-010-2682-4 |
| 英文摘要 | Inonotus obliquus (Fr.) Pilat is a white rot fungus belonging to the family Hymenochaetaceae in the Basidiomycota. In nature, this fungus rarely forms a fruiting body but usually an irregular shape of sclerotial conk called 'Chaga'. Characteristically, I. obliquus produces massive melanins released to the surface of Chaga. As early as in the sixteenth century, Chaga was used as an effective folk medicine in Russia and Northern Europe to treat several human malicious tumors and other diseases in the absence of any unacceptable toxic side effects. Chemical investigations show that I. obliquus produces a diverse range of secondary metabolites including phenolic compounds, melanins, and lanostane-type triterpenoids. Among these are the active components for antioxidant, antitumoral, and antiviral activities and for improving human immunity against infection of pathogenic microbes. Geographically, however, this fungus is restricted to very cold habitats and grows very slowly, suggesting that Chaga is not a reliable source of these bioactive compounds. Attempts for culturing this fungus axenically all resulted in a reduced production of bioactive metabolites. This review examines the current progress in the discovery of chemical diversity of Chaga and their biological activities and the strategies to modulate the expression of desired pathways to diversify and up-regulate the production of bioactive metabolites by the fungus grown in submerged cultures for possible drug discovery. |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000279200600005 |
| 出版者 | SPRINGER |
| 源URL | [http://210.72.129.5/handle/321005/121577]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Zheng, Weifa |
| 作者单位 | 1.Xuzhou Normal Univ, Sch Life Sci, Xuzhou 221116, Peoples R China 2.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110116, Peoples R China 3.Xuzhou Normal Univ, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Weifa,Miao, Kangjie,Liu, Yubing,et al. Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2010,87(4):1237-1254. |
| APA | Zheng, Weifa.,Miao, Kangjie.,Liu, Yubing.,Zhao, Yanxia.,Zhang, Meimei.,...&Dai, Yucheng.(2010).Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,87(4),1237-1254. |
| MLA | Zheng, Weifa,et al."Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 87.4(2010):1237-1254. |
入库方式： OAI收割
来源：沈阳应用生态研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。