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iASPP Is Important for Bladder Cancer Cell Proliferation

文献类型：期刊论文

作者Liu, Tao2; Li, Lin3; Yang, WenFeng4; Jia, Hui1; Xu, MingKai5; Bi, JianBin2; Li, ZeLiang2; Liu, XianKui2; Li, ZhenHua2; Jing, HongWei2
刊名ONCOLOGY RESEARCH
出版日期2010
卷号19期号:3-4页码:125-130
关键词Iaspp Rna Interference Bladder Cancer Proliferation
ISSN号0965-0407
DOI10.3727/096504011X12935427587768
英文摘要Inhibitor of apoptosis stimulatory protein phosphatase (iASPP) is a key inhibitor of p53 conserved from worm to human and is associated with cell proliferation and carcinogenesis in a variety of human cancers. Because iASPP is important for tumor cell apoptosis, it is a potential target for cancer gene therapy. However, it is still not clear whether iASPP is relevant to p53-deficient human bladder cancer. In the present study, iASPP was knocked down in bladder carcinoma 5637 and T24 cells (p53 defective) by lentiviral-mediated interfering short hairpin RNAs (siRNAs). MTT assay, BrdU incorporation assay, and colony formation assay were performed to investigate the role of iASPP on cell proliferation. It was suggested that iASPP knockdown led to cell growth deceleration and slow colony formation. A positive relationship between expression of iASPP and bladder cancer proliferation was found. The expression of iASPP may be critical for proliferation of bladder cancer cells. Our study indicates iASPP could be an important target for therapy in bladder cancer.
WOS研究方向Oncology
语种英语
WOS记录号WOS:000287959700004
出版者COGNIZANT COMMUNICATION CORP
源URL[http://210.72.129.5/handle/321005/121653]  
专题中国科学院沈阳应用生态研究所
通讯作者Kong, ChuiZe
作者单位1.China Med Univ, Dept Year 7, Shenyang 110001, Peoples R China
2.China Med Univ, Dept Urol, Affiliated Hosp 1, Shenyang 110001, Peoples R China
3.Guangdong Gen Hosp, Dept Rehabil, Guangzhou, Guangdong, Peoples R China
4.Handan Cent Hosp, Dept Urol, Handan, Hebei, Peoples R China
5.Chinese Acad Sci, Inst Appl Ecol, Shenyang, Liaoning, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Tao,Li, Lin,Yang, WenFeng,et al. iASPP Is Important for Bladder Cancer Cell Proliferation[J]. ONCOLOGY RESEARCH,2010,19(3-4):125-130.
APA Liu, Tao.,Li, Lin.,Yang, WenFeng.,Jia, Hui.,Xu, MingKai.,...&Kong, ChuiZe.(2010).iASPP Is Important for Bladder Cancer Cell Proliferation.ONCOLOGY RESEARCH,19(3-4),125-130.
MLA Liu, Tao,et al."iASPP Is Important for Bladder Cancer Cell Proliferation".ONCOLOGY RESEARCH 19.3-4(2010):125-130.

入库方式： OAI收割

来源：沈阳应用生态研究所

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