Study of Potential Biomarkers in Milk from Cows Treated with Chloramphenicol by Metabonomic Approach
文献类型：期刊论文
| 作者 | Wang Shi-Cheng; Wang Yan-Hong; Li Guo-Chen; Hu Xiao-Yan; Zhang Hong |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 38期号:8页码:1199-1202 |
| 关键词 | Milk Chloramphenicol Metabonomics Biomarker Hydroxyl-octadecadienoic Acid |
| ISSN号 | 0253-3820 |
| DOI | 10.3724/SP.J.1096.2010.01199 |
| 英文摘要 | HPLC-MS-based metabonomic approach was established for the metabonomic analysis of milk components between normal cows and cows treated with chloramphenicol. Endogenous metabolites of the milk samples were analyzed by HPLC-MS after the extraction and. The results showed that; (1) After chloramphenicol was injected, from the corresponding chromatographs, it was found that the treated group and the control group were significantly different, in which some peaks changed regularly with the medicine-treated time, (2) The control group and treated group were successfully discriminated by partial least squares discriminant analysis (PLS-DA), (3) Molecular formula of one indicating peak was C(18)H(32)O(3), hydroxyl-octadecadienoic acid (HODE), which could be the potential biomarker indicating the metabolic response to chloramphenicol. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000281530100023 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://210.72.129.5/handle/321005/121659]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Wang Yan-Hong |
| 作者单位 | Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Shi-Cheng,Wang Yan-Hong,Li Guo-Chen,et al. Study of Potential Biomarkers in Milk from Cows Treated with Chloramphenicol by Metabonomic Approach[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2010,38(8):1199-1202. |
| APA | Wang Shi-Cheng,Wang Yan-Hong,Li Guo-Chen,Hu Xiao-Yan,&Zhang Hong.(2010).Study of Potential Biomarkers in Milk from Cows Treated with Chloramphenicol by Metabonomic Approach.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,38(8),1199-1202. |
| MLA | Wang Shi-Cheng,et al."Study of Potential Biomarkers in Milk from Cows Treated with Chloramphenicol by Metabonomic Approach".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 38.8(2010):1199-1202. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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