Potent Toxic Macrocyclic Trichothecenes from the Marine-Derived Fungus Myrothecium verrucaria Hmp-F73
文献类型：期刊论文
| 作者 | Zhao, Li1,2; Liu, Li1; Wang, Nan2; Wang, Shu-Jin1; Hu, Jing-Chun1; Gao, Jin-Ming2 |
| 刊名 | NATURAL PRODUCT COMMUNICATIONS
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 6期号:12页码:1915-1916 |
| ISSN号 | 1934-578X |
| 关键词 | Myrothecium Verrucaria Hmp-f73 Hymeniacidon Perleve Trichothecenes Mycotoxins Brine Shrimp Lethality |
| 英文摘要 | Activity-guided fractionation of a methanol extract from the culture broth of Myrothecium verrucaria Hmp-F73, a fungus associated with the sponge Hymeniacidon perleve, afforded six macrocyclic trichothecenes, verrucarin J (1), 8-hydroxyverrucarin J (2), verrucarin A (3), 8-acetoxyroridin (4), isororidin E (5), and roridin E (6), along with trichoverrin B (7). All seven metabolites displayed potent toxicity to the brine shrimp (Artemia sauna). In addition, compounds 2, 3, and 6 showed weak phytotoxic activities against lettuce seeds. A preliminary structure-activity relationship of the metabolites is also discussed. |
| WOS研究方向 | Pharmacology & Pharmacy ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | NATURAL PRODUCTS INC |
| WOS记录号 | WOS:000298445300031 |
| 源URL | [http://210.72.129.5/handle/321005/121783]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Hu, Jing-Chun |
| 作者单位 | 1.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110161, Peoples R China 2.NW A&F Univ, Coll Sci, Res Ctr Nat Med Chem, Yangling 712100, Shaanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Li,Liu, Li,Wang, Nan,et al. Potent Toxic Macrocyclic Trichothecenes from the Marine-Derived Fungus Myrothecium verrucaria Hmp-F73[J]. NATURAL PRODUCT COMMUNICATIONS,2011,6(12):1915-1916. |
| APA | Zhao, Li,Liu, Li,Wang, Nan,Wang, Shu-Jin,Hu, Jing-Chun,&Gao, Jin-Ming.(2011).Potent Toxic Macrocyclic Trichothecenes from the Marine-Derived Fungus Myrothecium verrucaria Hmp-F73.NATURAL PRODUCT COMMUNICATIONS,6(12),1915-1916. |
| MLA | Zhao, Li,et al."Potent Toxic Macrocyclic Trichothecenes from the Marine-Derived Fungus Myrothecium verrucaria Hmp-F73".NATURAL PRODUCT COMMUNICATIONS 6.12(2011):1915-1916. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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