Design, Synthesis, and Bioactivities Screening of a Diaryl Ketone-Inspired Pesticide Molecular Library as Derived from Natural Products
文献类型：期刊论文
| 作者 | Zhang, Hong1,5; Jin, Hong3; Ji, Lan-zhu5; Tao, Ke4; Liu, Wei2; Zhao, Hao-yu4; Hou, Tai-ping4 |
| 刊名 | CHEMICAL BIOLOGY & DRUG DESIGN
 |
| 出版日期 | 2011-07-01 |
| 卷号 | 78期号:1页码:94-100 |
| 关键词 | Antifungal Activity Bioactivity Diaryl Ketones Pesticide Synthesis |
| ISSN号 | 1747-0277 |
| DOI | 10.1111/j.1747-0285.2011.01082.x |
| 英文摘要 | Three natural products, 1,5-diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi. The IC(50) of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III(2)) was 1.20 mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000292695900010 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://210.72.129.5/handle/321005/121979]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Tao, Ke |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 2.Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China 3.Sichuan Univ, Coll Chem, Chengdu 610064, Sichuan, Peoples R China 4.Sichuan Univ, Coll Life Sci, Chengdu 610064, Sichuan, Peoples R China 5.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hong,Jin, Hong,Ji, Lan-zhu,et al. Design, Synthesis, and Bioactivities Screening of a Diaryl Ketone-Inspired Pesticide Molecular Library as Derived from Natural Products[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2011,78(1):94-100. |
| APA | Zhang, Hong.,Jin, Hong.,Ji, Lan-zhu.,Tao, Ke.,Liu, Wei.,...&Hou, Tai-ping.(2011).Design, Synthesis, and Bioactivities Screening of a Diaryl Ketone-Inspired Pesticide Molecular Library as Derived from Natural Products.CHEMICAL BIOLOGY & DRUG DESIGN,78(1),94-100. |
| MLA | Zhang, Hong,et al."Design, Synthesis, and Bioactivities Screening of a Diaryl Ketone-Inspired Pesticide Molecular Library as Derived from Natural Products".CHEMICAL BIOLOGY & DRUG DESIGN 78.1(2011):94-100. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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