Maternal transfer and reproductive effects of Cr(VI) in Japanese medaka (Oryzias latipes) under acute and chronic exposures
文献类型：期刊论文
| 作者 | Klerks, Paul L.3; Chen, Hongxing2; Cao, Jinling1; Li, Lixia2; Wu, Xing2; Bi, Ran2; Xie, Lingtian2 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 171页码:59-68 |
| 关键词 | Chromium Accumulation Maternal Transfer Reproduction Japanese Medaka |
| ISSN号 | 0166-445X |
| DOI | 10.1016/j.aquatox.2015.12.011 |
| 英文摘要 | Maternal transfer of metals can be an important exposure route for animals. The maternal transfer of Cr and its effects on reproduction in fish are still largely unknown. In this study, Japanese medaka were exposed to a sublethal Cr(VI) concentration for 6 days (acute) and for 3 months (chronic). Chromium accumulation in the gonads, maternal transfer of Cr, and effects of Cr on the reproduction, histopathology and expressions of antioxidants in the gonads were evaluated. Both acute and chronic exposures resulted in significant Cr accumulation in gonads, eggs and larvae. In chronic Cr-exposed fish, approximately 61% of the Cr accumulated in the ovary was depurated by spawning during the first 3 days after exposure, suggesting that maternal transfer is a very important pathway for accumulation in offspring. The chronic exposure caused decreases in body weight, standard length, gonad weight, gonad-somatic index (GSI) and fecundity. The last of these was most severely affected: the total number of broods and eggs per female decreased by 57.1% and 75.9%, respectively. Moreover, egg weight and fertilization rate were also reduced (by approximately 20%) following chronic Cr(VI) exposure. Histopathological analyses showed that the Cr exposure resulted in the onset of follicular atresia and a reduction in the number of mature oocytes, along with a reduction in abundance of mature spermatozoa in testes. The GSH/GSSG ratio was greatly elevated after chronic Cr(VI) exposure, implying that GSH played a role in scavenging the reactive oxygen species generated by the reduction of Cr(VI) inside cells. This study provides evidence for the maternal transfer of Cr, highlights the importance of spawning in Cr depuration from the ovary, and demonstrates that chronic Cr(VI) exposure has serious impacts on reproduction in the Japanese medaka. Our results suggest that the issue of chronic Cr pollution deserves more attention than it has received to date. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS研究方向 | Marine & Freshwater Biology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000369214100007 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://210.72.129.5/handle/321005/122443]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Xie, Lingtian |
| 作者单位 | 1.Shanxi Agr Univ, State Key Lab Ecol Anim Husb & Environm Vet Med, Taigu 030801, Shanxi, Peoples R China 2.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang 110016, Liaoning, Peoples R China 3.Univ Louisiana Lafayette, Dept Biol, POB 43602, Lafayette, LA 70504 USA |
| 推荐引用方式 GB/T 7714 | Klerks, Paul L.,Chen, Hongxing,Cao, Jinling,et al. Maternal transfer and reproductive effects of Cr(VI) in Japanese medaka (Oryzias latipes) under acute and chronic exposures[J]. AQUATIC TOXICOLOGY,2016,171:59-68. |
| APA | Klerks, Paul L..,Chen, Hongxing.,Cao, Jinling.,Li, Lixia.,Wu, Xing.,...&Xie, Lingtian.(2016).Maternal transfer and reproductive effects of Cr(VI) in Japanese medaka (Oryzias latipes) under acute and chronic exposures.AQUATIC TOXICOLOGY,171,59-68. |
| MLA | Klerks, Paul L.,et al."Maternal transfer and reproductive effects of Cr(VI) in Japanese medaka (Oryzias latipes) under acute and chronic exposures".AQUATIC TOXICOLOGY 171(2016):59-68. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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