Superantigen staphylococcal enterotoxin C1 mutant can reduce paraquat pulmonary fibrosis
文献类型：期刊论文
| 作者 | Wang, Nana3; Li, Tiegang2; Xu, Mingkai1; Zhao, Min2 |
| 刊名 | TOXICOLOGY MECHANISMS AND METHODS
 |
| 出版日期 | 2015 |
| 卷号 | 25期号:7页码:574-580 |
| 关键词 | Paraquat Pulmonary Fibrosis Staphylococcal Enterotoxin C1 Superantigen |
| ISSN号 | 1537-6516 |
| DOI | 10.3109/15376516.2015.1056863 |
| 英文摘要 | A network of inflammation factors is related to pulmonary fibrosis induced by paraquat (PQ) poisoning. At high doses, the superantigen staphylococcal enterotoxin C1 (SEC1) can induce immunological unresponsiveness and inhibit release of inflammation factors. In this study, site-directed mutagenesis was performed at the H118 and H122 amino acid residues of SEC1 to reduce SEC1 toxicity. The SEC1 mutant showed significantly decreased pyrogenic toxicity, but retained clonal anergy at high dosages in vitro. Pretreatment with the SEC1 mutant prior to PQ poisoning in mice reduced symptom duration and severity, prolonged survival time, and decreased the splenocyte response to ConA induction. The SEC1 mutant also down-regulated several important cytokines related to fibrosis in the plasma after PQ poisoning. SEC1 decreased the expression of genes related to pulmonary fibrosis, including alpha-SMA, COL1a1, COL3 and TGF-beta 1, in PQ poisoned mice. Histomorphological observation indicated alleviation of pathological changes in the lungs after SEC1 pretreatment compared to mice in the PQ group. In conclusion, the SEC1 mutant reduced pulmonary interstitial fibrosis induced by PQ poisoning. |
| WOS研究方向 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000369821700009 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://210.72.129.5/handle/321005/122467]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Zhao, Min |
| 作者单位 | 1.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Peoples R China 2.China Med Univ, Shengjing Hosp, Emergency Dept, 36 Sanhao St, Shenyang 110004, Peoples R China 3.China Med Univ, Dept Endocrinol, Shengjing Hosp, Shenyang 110004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Nana,Li, Tiegang,Xu, Mingkai,et al. Superantigen staphylococcal enterotoxin C1 mutant can reduce paraquat pulmonary fibrosis[J]. TOXICOLOGY MECHANISMS AND METHODS,2015,25(7):574-580. |
| APA | Wang, Nana,Li, Tiegang,Xu, Mingkai,&Zhao, Min.(2015).Superantigen staphylococcal enterotoxin C1 mutant can reduce paraquat pulmonary fibrosis.TOXICOLOGY MECHANISMS AND METHODS,25(7),574-580. |
| MLA | Wang, Nana,et al."Superantigen staphylococcal enterotoxin C1 mutant can reduce paraquat pulmonary fibrosis".TOXICOLOGY MECHANISMS AND METHODS 25.7(2015):574-580. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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